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1)Young T, Finn L, Peppard PE, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008; 31: 1071-8
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2)Shahar E, Whitney CW, Redline S, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001; 163: 19-25
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3)Muraki I, Tanigawa T, Yamagishi K, et al. Nocturnal intermittent hypoxia and metabolic syndrome; the effect of being overweight: the CIRCS study. J Atheroscler Thromb. 2010; 17: 369-77
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4)Suzuki T, Nakano H, Maekawa J, et al. Obstructive sleep apnea and carotid-artery intima-media thickness. Sleep. 2004; 27: 129-33
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5)Tamaki S, Yamauchi M, Kimura H, et al. Nocturnal hypoxic stress activates invasive ability of monocytes in patients with obstructive sleep apnoea syndrome. Respirology. 2009; 14: 689-94
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6)Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by inter-mittent hypoxia in obstructive sleep apnea syndrome. Circulation. 2005; 112: 2660-7
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7)Tamaki S, Yamauchi M, Kimura H, et al. Production of inflammatory mediators by monocytes in patients with obstructive sleep apnea syndrome. Intern Med. 2009; 48: 1255-62
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8)Yoshikawa M, Yamauchi M, Kimura H, et al. The Impact of obstructive sleep apnea and nasal CPAP on circulating adiponectin levels. Lung. 2014; 192: 289-95
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9)Koyama N, Matsumoto M, Kimura H, et al. Reduced larger VWF multimers at dawn in OSA plasmas reflect severity of apneic episodes. Eur Respir J. 2012; 40: 657-64
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10)Reichmuth KJ, Austin D, Skatrud JB, et al. Association of sleep apnea and typeⅡ diabetes: a population-based study. Am J Respir Crit Care Med. 2005; 172: 1590-5
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11)Ota H, Tamaki S, Kimura H, et al. Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38. Life Sci. 2012; 90: 206-11
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12)Ota H, Itaya-Hironaka S, Kimura H, et al. Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Life Sci. 2013; 93: 664-72
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13)Kyotani Y, Ota H, Kimura H, et al. Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor. Exp Cell Res. 2013; 319: 3042-50
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14)Nieto FJ, Peppard PE, Young T, et al. Sleep-disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study. Am J Resp Crit Cere Med. 2012; 186: 190-4
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15)Campos-Rodriguez1 F, Martinez-Garcia MA, Martinez M, et al. Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort. Am J Respir Crit Care Med. 2013; 198: 99-105
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16)Chang WP, Liu ME, Chang WC, et al. Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study. Sleep Med. 2014; 15: 1016-20
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17)Almendros I, Wang Y, Becker L, et al. Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea. Am J Respir Crit Care Med. 2014; 189: 593-601
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18)Miller J, Edwards LD, Agusti A, et al. Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med. 2013; 107: 1376-84
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19)Agusti A, Edwards LD, Celli B, et al. Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort. Eur Respir J. 2013; 42: 636-46
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20)木村 弘,慢性閉塞性肺疾患(COPD)の栄養状態および併存症の実態調査.厚生労働省呼吸不全調査研究班平成20年度研究報告書.2009. p. 247-51
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21)Yamamoto Y, Yoshikawa M, Kimura H, et al. Distribution of bone mineral content is associated with body weight and exercise capacity in patients with COPD. Respiration. 2014; 87: 158-64
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22)Yoshikawa M, Fujita Y, Kimura H, et al. The Mini Nutritional Assessment Short-form predicts exacerbation frequency in patients with chronic obstructive pulmonary disease. Respirology. 2014; 19: 1198-203
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23)吉川雅則,木村 弘.COPD.診断と治療の進歩.合併症(全身併存症)-栄養障害. 日内会誌.2012; 101: 1562-70
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24)Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010; 39: 412-23
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25)Jones SE, Maddocks M, Kon SS, et al. Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax. 2015; 70: 213-8
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26)Maddocks M, Shrikrishna D, Vitoriano S, et al. Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD. Eur Resp J. 2014; 44: 1188-98
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27)Schols AM, Ferreira IM, Franssen FM, et al. Nutritional assessment and therapy in COPD: a European Respiratory Society statement. Eur Respir J. 2014; 44: 1504-20
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28)Ji LL, Kang C. Role of PGC-1α in sarcopenia: etiology and potential intervention-a mini-review. Gerontology. 2015; 61: 139-48
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29)Miki K, Maekura R, Kimura H, et al. Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial. PLoS One. 2012; 7: e35708
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30)Matsumoto N, Miki K, Kimura H, et al. Ghrelin administration for chronic respiratory failure: A randomized dose-comparison trial. Lung. 2015; 193: 239-47
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31)Tomoda K, Kubo K, Kimura H, et al. Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats. J Toxicol Sci. 2011; 36: 261-66
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32)Tomoda K, Kubo K, Asahara T, Kimura H, et al. Suppressed anti-oxidant capacity due to a cellulose-free diet declines further by cigarette smoke in mice. J Toxicol Sci. 2012; 37: 575-85
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33)Tomoda K, Yoshikawa M, Kimura H, et al. Elevated circulating plasma adiponectin in underweight patients with COPD. Chest. 2007; 132: 135-40
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34)Yoon HI, Li Y, Man SF, et al. The complex relationship of serum adiponectin to COPD outcomes COPD and adiponectin. Chest. 2012; 142: 893-99
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35)Sato K, Shibata Y, Abe S, et al. Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese poulation: the Takahata study. Int J Med Sci. 2014; 11: 758-64
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36)Nakanishi K, Takeda Y, Tetsumoto S, et al. Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice: implications for therapy. Am J Resp Crit Cere Med. 2011; 183: 1164-75
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