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2)Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol. 2002; 13: 3005-15
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3)Kawachi H, Suzuki K, Miyauchi N, et al. Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome. Clin Exp Nephrol. 2009; 13: 275-80
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4)Winn MP, Conlon PJ, Lynn KL, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science. 2005; 308: 1801-4
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5)Eckel J, Lavin PJ, Finch EA, et al. TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol. 2011; 22: 526-35
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6)Clement LC, Macé C, Avila-Casado C, et al. Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med. 2014; 20: 7-46
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7)Hasegawa K, Wakino S, Simic P, et al. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med. 2013; 19: 1496-504
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8)Tian X, Kim JJ, Monkley SM, et al. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. J Clin Invest. 2014; 124: 1098-113
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9)Chen YM, Zhou Y, Go G, et al. Laminin β2 gene missense mutation produces endoplasmic reticulum stress in podocytes. J Am Soc Nephrol. 2013; 24: 1223-33
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10)Singh A, Fridén V, Dasgupta I, et al. High glucose causes dysfunction of the human glomerular endothelial glycocalyx. Am J Physiol Renal Physiol. 2011; 300: F40-8
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11)Clement LC, Avila-Casado C, Macé C, et al. Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 2011; 17: 117-22
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12)El-Aouni C, Herbach N, Blattner SM, et al. Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol. 2006; 17: 1334-44
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13)Suh JH, Miner JH. The glomerular basement membrane as a barrier to albumin. Nat Rev Nephrol. 2013: 9: 470-7
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14)Jarad G, Cunningham J, Shaw AS, et al. Proteinuria precedes podocyte abnormalities in Lamb2-/-mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest. 2006; 16: 2272-9
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15)Suh JH, Miner JH. The glomerular basement membrane as a barrier to albumin. Nat Rev Nephrol. 2013; 9: 470-7
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16)Suh JH, Jarad G, VanDeVoorde RG, et al. Forced expression of laminin beta1 in podocytes prevents nephrotic syndrome in mice lacking laminin beta2, a model for Pierson syndrome. Proc Natl Acad Sci U S A. 2011; 108: 15348-53
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18)Singh A, Fridén V, Dasgupta I, et al. High glucose causes dysfunction of the human glomerular endothelial glycocalyx. Am J Physiol Renal Physiol. 2011; 300: F40-8
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19)Salmon AH, Ferguson JK, Burford JL, et al. Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction. J Am Soc Nephrol. 2012; 23: 1339-50
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20)Armelloni S, Calvaresi N, Ikehata M,et al. Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet. Nephron Exp Nephrol. 2012; 120: e69-80
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21)Miyauchi N, Saito A, Karasawa T, et al. Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli. J Am Soc Nephrol. 2006; 17: 2748-59
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22)Saito A, Miyauchi N, Hashimoto T, et al. Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys. Am J Physiol Regul Integr Comp Physiol. 2011; 300: R340-8
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23)Schießl IM, Castrop H. Angiotensin II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin: a multiphoton microscopy study. Am J Physiol Renal Physiol. 2013; 305: F1189-200
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24)Suzuki K, Han GD, Miyauchi N, et al. Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. Am J Pathol. 2007; 170: 1841-53
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25)Faul C, Donnelly M, Merscher-Gomez S, et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med. 2008; 14: 931-8
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26)Schlöndorff J, Del Camino D, Carrasquillo R, et al. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am J Physiol Cell Physiol. 2009; 296: C558-69
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27)Nijenhuis T, Sloan AJ, Hoenderop JG, et al. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol. 2011; 179: 1719-32
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28)Lal MA, Andersson AC, Katayama K, et al. Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration. J Am Soc Nephrol. 2014 [Epub ahead of print]
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29)Tanaka E, Asanuma K, Kim E, et al. Notch2 activation ameliorates nephrosis. Nat Commun. 2014; 5: 3296
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30)Bi J, Chase SE, Pellenz CD, et al. Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes. 2013; 305: F532-44
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32)Yamada S, Nakamura J, Asada M, et al. Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS One. 2014; 9: e89135
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