|
1）Lowell BB, S-Susulic V, Hamann A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993; 366: 740-2
|
|
|
|
2）Feldmann HM, Golozoubova V, Cannon B, et al. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009; 9: 203-9
|
|
|
|
|
|
3）Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology. 1996; 137: 21-9
|
|
|
|
|
|
4）Nishio M, Yoneshiro T, Nakahara M, et al. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab. 2012; 16: 394-406
|
|
|
|
|
|
5）Stanford KI, Middelbeek RJ, Townsend KL, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013; 123: 215-23
|
|
|
|
|
|
6）Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011; 17: 200-5
|
|
|
|
|
|
7）Mantzoros CS, Frederich RC, Qu D, et al. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes. 1998; 47: 230-8
|
|
|
|
|
|
8）Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008; 454: 961-7
|
|
|
|
|
|
9）Tran KV, Gealekman O, Frontini A, et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012; 15: 222-9
|
|
|
|
|
|
10）Gupta RK, Arany Z, Seale P, et al. Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010; 464: 619-23
|
|
|
|
|
|
11）Rosenwald M, Perdikari A, Rülicke T, et al. Bi-directional interconversion of brite and white adipocytes. Nat Cell Biol. 2013; 15: 659-67
|
|
|
|
|
|
12）van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009; 360: 1500-8
|
|
|
|
|
|
13）Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009; 360: 1509-17
|
|
|
|
|
|
14）Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009; 360: 1518-25
|
|
|
|
|
|
15）Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009; 58: 1526-31
|
|
|
|
|
|
16）Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012; 150: 366-76
|
|
|
|
|
|
17）Sharp LZ, Shinoda K, Ohno H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012; 7: e49452
|
|
|
|
|
|
18）Cypess AM, White AP, Vernochet C, et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013; 19: 635-9
|
|
|
|
|
|
19）Timmons JA, Wennmalm K, Larsson O, et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A. 2007; 104: 4401-6
|
|
|
|
|
|
20）Waldén TB, Hansen IR, Timmons JA, et al. Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues. Am J Physiol Endocrinol Metab. 2012; 302: E19-31
|
|
|
|
|
|
21）Yoneshiro T, Aita S, Matsushita M, et al. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity. 2011; 19: 13-6
|
|
|
|
|
|
22）会田さゆり，米代武司，波多野卓也，他．成人における食後熱産生に対する褐色脂肪の寄与．肥満研究．2011; 17: 41-8
|
|
|
|
|
23）Yoneshiro T, Aita S, Matsushita M, et al. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity. 2011; 19: 1755-60
|
|
|
|
|
|
24）Yoneshiro T, Aita S, Kawai Y, et al. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr. 2012; 95: 845-50
|
|
|
|
|
|
25）Yoneshiro T, Aita S, Matsushita M, et al. Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest. 2013; 123: 3404-8
|
|
|
|
|
|
26）佐伯久美子．ヒト多能性幹細胞由来褐色脂肪細胞．In: 門脇 孝，編．糖尿病学2013．東京: 診断と治療社; 2013; p.63-72
|
|
|
|
|
|
27）Ahfeldt T, Schinzel RT, Lee YK, et al. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012; 14: 209-19
|
|
|
|
|
|
28）Wakao S, Kitada M, Kuroda Y, et al. Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci U S A. 2011; 108: 9875-80
|
|
|
|
|
|
29）Enerbäck S, Jacobsson A, Simpson EM, et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature. 1997; 387: 90-4
|
|
|
|
|
|
30）Liu X, Rossmeisl M, McClaine J, et al. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest. 2003; 111: 399-407
|
|
|
|
|
|
31）Okamatsu-Ogura Y, Nio-Kobayashi J, Iwanaga T, et al. Possible involvement of uncoupling protein 1 in appetite control by leptin. Experimental Biology and Medicine. 2011; 236: 1274-81
|
|
|
|
|