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3）上野眞二，村松慎一．Alzheimer病と漢方薬．神経内科．2012; 76: 147-54

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5）Higashi K, Rakugi H, Yu H, et al. Effect of kihito extract granules on cognitive function in patients with Alzheimerʼs-type dementia. Geriatr Gerontol Int. 2007; 7: 245-51

6）荒井啓行，鈴木朋子，佐々木英忠，他．アルツハイマー病の薬物療法—加味温胆湯による治療介入の試み．日本老年医学会雑誌．2000; 37: 212-5

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12）Iwasaki K, Satoh-Nakagawa T, Maruyama M, et al. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry. 2005; 66: 248-50

13）Mizukami K, Asada T, Kinoshita T, et al. A randomized cross-over study of traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. Int J Neuropsychopharmacol. 2009; 12: 191-9

14）Hayashi Y, Ishida Y, Inoue T, et al. Treatment of behavioral and psychological symptoms of Alz-heimer-type dementia with Yokukansan in clinical practice. Prog Neuropsychoparmacol Biol Psychiatry. 2010; 34: 541-5

15）Okahara K, Ishida Y, Hayashi Y, et al. Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimerʼs disease. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34: 532-6

16）Matsuda Y, Kishi T, Shibayama H, et al. Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials. Hum Psychopharmacol. 2013; 28: 80-6

17）Nogami A, Sakata Y, Uchida N, et al. Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia. J Nat Med. 2011; 65: 275-81

18）Yamaguchi T, Tsujimatsu A, Kumamoto H, et al. Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. J Ethnopharmacol. 2012; 143: 533-9

19）Imamura S, Tabuchi M, Kushida H, et al. The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan. Cell Mol Neurobiol. 2011; 31: 787-93

20）Nishi A, Yamaguchi T, Sekiguchi K, et al. Geissoschizine methyl ether, an alkaloid in uncaria hook, is a potent serotonin1A receptor agonist and candidate for amelioration of aggressiveness and sociality by Yokukansan. Neuroscience. 2012; 207: 124-36

21）Ueki T, Nishi A, Imamura S, et al. Effects of geissoschizine methyl ether, an indole alkaloid in uncaria hook, a constituent of Yokukansan, on human recombinant serotonin7 receptor. Cell Mol Neurobiol. 2013; 33: 129-35

22）Fujiwara H, Takayama S, Iwasaki K, et al. Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice. Neuroscience. 2011; 180: 305-13

23）Ikarashi Y, Iizuka S, Imamura S, et al. Effect of yokukansan, a Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biol Pharm Bull. 2009; 32: 1701-9

24）Yamaguchi T, Sekiguchi K, Kawakami Z, et al. Remedial effects of Yokukansan, a Kampo medicine, on social interactive deficits in thiamine-deficient mice. Phytopharmacology. 2011; 1: 123-37

25）Sekiguchi K, Kanno H, Yamaguchi T, et al. Ameliorative effect of yokukansan on vacuous chewing movement in haloperidol-induced rat tardive dyskinesia model and involvement of glutamatergic system. Brain Res Bull. 2012; 89: 151-8

26）Suzuki Y, Mitsuhata H, Yuzurihara M, et al. Antiallodynic effect of herbal medicine Yokukansan on peripheral neuropathy in rats with chronic constriction injury. Evid Based Complement Alternat Med. 2012; 2012: 953459

27）Tabuchi M, Imamura S, Kawakami Z, et al. The blood-brain barrier permeability of 18β-glycyrrheti-nic acid, a major metabolite of glycyrrhizin in glycyrrhiza root, a constituent of the traditional Japanese medicine Yokukansan. Cell Mol Neurobiol. 2012; 32: 1139-46

28）Kawakami Z, Ikarashi Y, Kase Y. Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes. Eur J Pharmacol. 2010; 626: 154-8

29）Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in Kampo medicine Yokukansan. Cell Mol Neurobiol. 2011; 31: 1203-12

30）Mizoguchi K, Shoji H, Tanaka Y, et al. Ameliorative effect of traditional Japanese medicine Yokukansan on age-related impairments of working memory and reversal learning in rats. Neurosci. 2011; 177: 127-37

31）Nakagawa T, Nagayasu K, Nishitani N, et al. Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α2A-adrenoceptor. Neuroscience. 2012; 227: 336-49

32）Hiratsuka T, Matsuzaki S, Miyata S, et al. Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response. PLoS One. 2010; 5: e13280

33）Egashira N, Nogami A, Iwasaki K, et al. Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: possible involvement of GABA(A)-benzodiazepine receptor complex. J Pharmacol Sci. 2011; 116: 316-20

34）Tohda C, Nakada R, Urano T, et al. Kamikihi-to (KKY) resucues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimerʼs disease, 5XFAD. Int J Neurosci. 2011; 121: 641-8

35）Toriizuka K, Hou P, Yabe T, et al. Effects of Kampo medicine, Toki-shakuyaku-san (Tang-Kuei-Shao-Yao-San), on choline acetyltransferase activity and norepinephrine contents in brain regions, and mitogenic activity of splenic lymphocytes in ovariectomized mice. J Ethnopharmacol. 2000; 71: 133-43

36）Matsuoka T, Narumoto J, Shibata K, et al. Effect of Toki-Shakuyaku-San on regional cerebral blood flow in patients with mild cognitive impairment and Alzheimerʼs disease. Evid Based Complement Alternat Med. 2012; 2012: 245091

37）Goto H, Satoh N, Hayashi Y, et al. A chinese herbal medicine, Tokisyakuyakusan, reduces the worsening of impairments and independence after stroke: A 1-year randomized, controlled trial. Evid Based Complement Alternat Med. 2011; 2011: 194046

38）Okamoto H, Chino A, Hirasaki Y, et al. Orengedoku-to augmentation in cases showing partial response to Yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae. Neuropsychiatr Dis Treat. 2012; 9: 151-5

39）Shibata K, Sugawara T, Fujishita K, et al. The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice. PLoS One. 2011; 6: e23510

40）Nakanishi M, Arimitsu J, Kageyama M, et al. Efficacy of traditional Japanese herbal medicines-Keishikajutsubuto (TJ-18) and Bushi-matsu (TJ-3022)-against postherpetic neuralgia aggravated by self-reported cold stimulation: a case series. J Alternat Complement Med. 2012; 18: 686-92

41）山田岳史，菅　隼人，松本智司，他．Oxaliplatinによる末梢神経障害に対する桂枝加朮附湯と附子の効果．癌と化学療法．2012; 39: 1687-91

42）Yoshiro H, Sekiya N, Chino A, et al. Three cases of chemotherapy-induced peripheral neuropathy successfully treated with therapy based on Kampo diagnosis. Alternat Ther. 2011; 17: 26-30

43）Kaku H, Kumagai S, Onoue H, et al. Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative study. Exper Ther Med. 2012; 3: 60-5

44）吉田直久，細川豊史，石川　剛，他．種々の癌腫の抗がん剤治療に伴う末梢神経障害に対する牛車腎気丸の有効性．Prog Med. 2012; 32: 2509-15

45）大西憲明，長澤一樹，横山照由．モデルマウスを用いた漢方方剤の利水作用の検証．和漢医薬学会雑誌．2000; 17: 131-6

46）磯濱洋一郎．和漢薬によるアクアポリン水チャンネルの機能調節．漢方と最新治療．2008; 17: 27-35

47）Kurita T, Nakamura K, Tabuchi M, et al. Effects of Gorei-san: A traditional Japanese Kampo medicine, on aquaporin 1, 2, 3, 4 and V2R mRNA expression in rat kidney and forebrain. J Med Sci. 2011; 11: 30-8

48）Utsuki S, Oka H, Kijima C, et al. Role of saireito in postoperative chronic subdural hematoma recurrence prevention. J Trad Med. 2012; 29: 137-42

49）牧野利明，大嶽信弘．甘草の副作用 偽アルドステロン症の発症メカニズムとその予防策について．ファルマシア．2011; 47: 403-7

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