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1)Luo Y, Raible D, Raper JA. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell. 1993; 75: 217-27
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2)Suzuki K, Kumanogoh A, Kikutani H. Semaphorins and their receptors in immune cell interactions. Nat Immunol. 2008; 9: 17-23
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3)Kumanogoh A, Watanabe C, Lee I, et al. Identification of CD72 as a lymphocyte receptor for the class IV semaphoring CD100: a novel mechanism for regulating B cell signaling. Immunity. 2000; 13: 621-31
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4)Kruger RP, Aurandt J, Guan K. Semaphorins command cells to move. Nat Rev Mol Cell Biol. 2008; 6: 789
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5)Takamatsu H, Takegahara N, Nakagawa Y, et al. Semaphorins guide the entry of dendric cells into the lymphatics by activating myosin 2. Nat Immunol. 2010; 7: 594-7
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6)Vadasz Z, Ben-Izhak O, Bejar J, et al. The involvement of immune semaphorins and neuropilin-1 in lupus nephritis. Lupus. 2011; 20: 1466-73
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7)Catalano A. The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis. J Immunol. 2010; 185: 6373-83
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8)Kang S, Kumanogoh A. Semaphorins in bone development, homeostasis, and disease. Semin Cell Dev Biol. 2013; 24: 163-71
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9)Takegahara N, Takamatsu H, Toyofuku T, et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol. 2006; 8: 615
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10)Negishi-Koga T, Shinohara M, Komatsu N, et al. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med. 2011; 17: 1473-80
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11)Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A. Nature. 2012; 485: 69-74
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12)Suzuki K, Okuno T, Yamamoto M, et al. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature. 2007; 446: 680-4
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13)Kang HR, Lee CG, Homer RJ, et al. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. J Exp Med. 2007; 204: 1083-93
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14)Reilkoff RA, Peng H, Murray LA, et al. Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis. Am J Respir Crit Care Med. 2013; 187: 180-8
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15)Kumanogoh A, Shikina T, Suzuki K, et al. Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. Immunity. 2005; 22: 305-16
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16)Nkyimbeng-Takwi EH, Shanks K, Smith E, et al. Neuroimmune semaphorin 4A downregulates the severity of allergic response. Mucosal Immunol. 2012; 5: 409-19
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17)Morihana T, Goya S, Mizui M, et al. An inhibitory role for Sema4A in antigen-specific allergic asthma. J Clin Immunol. 2013; 33: 200-9
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18)Messersmith EK, Leonardo ED, Shatz CJ, et al. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron. 1995; 14: 949-59
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19)Yamaguchi J, Nakamura F, Aihara M, et al. Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model. J Invest Dermatol. 2008; 128: 2842-9
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20)Tamagnone L. Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer. Cancer Cell. 2012; 22: 145-52
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21)Potiron VA, Roche J, Drabkin HA. Semaphorins and their receptors in lung cancer. Cancer Lett. 2009; 273: 1-14
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22)Castro-Rivera E, Ran S, Brekken RA, et al. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Res. 2008; 68: 8295-303
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23)Sierra JR, Corso S, Caione L, et al. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macro- phages. J Exp Med. 2008; 205: 1673-85
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24)Capparuccia L, Tamagnone L. Semaphorin signaling in cancer cells and in cells of the tumor microenvironment-two sides of a coin. J Cell Sci. 2009; 122(Pt 11): 1723-36
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26)Maione F, Molla F, Meda C, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest. 2009; 119: 3356-72
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