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2)Colasanti T, Alessandri C, Capozzi A, et al. Autoantibodies specific to a peptide of beta 2-glycoprotein I cross-react with TLR4, inducing a proinflammatory phenotype in endothelial cells and monocytes. Blood. 2012; 120(16): 3360-70
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3)de Laat B, Derksen RH, Urbanus RT, et al. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood. 2005; 105(4): 1540-5
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4)de Laat B, van Berkel M, Urbanus RT, et al. Immune responses against domain I of beta(2)-glycoprotein I are driven by conformational changes: domain I of beta(2)-glycoprotein I harbors a cryptic immunogenic epitope. Arthritis Rheum. 2011; 63(12): 3960-8
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5)Andreoli L, Nalli C, Motta M, et al. Anti-beta(2)-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: might it be the reason for their ‘innocentʼ profile? Ann Rheum Dis. 2011; 70(2): 380-3
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6)Sakai Y, Atsumi T, Ieko M, et al. The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation. Arthritis Rheuma. 2009; 60(8): 2457-67. PubMed PMID: 19644870
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7)Akhter E, Shums Z, Norman GL, et al. Utility of antiphosphatidylserine/prothrombin and IgA antiphospholipid assays in systemic lupus erythematosus. J Rheumatol. 2013; 40(3): 282-6. PubMed PMID: 23378459
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8)Pengo V, Ruffatti A, Legnani C, et al. Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood. 2011; 118(17): 4714-8
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9)Gris JC, Bouvier S, Molinari N, et al. Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study. Blood. 2012; 119(11): 2624-32
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10)Otomo K, Atsumi T, Amengual O, et al. Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events. Arthritis Rheum. 2012; 64(2): 504-12
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12)Agar C, van Os GM, Morgelin M, et al. Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome. Blood. 2010; 116(8): 1336-43
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13)Van OSG, Meijers JC, Agar C, et al. Induction of anti-beta2 -glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes. J Thromb Haemost. 2011; 9(12): 2447-56
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14)Ioannou Y, Zhang JY, Qi M, et al. Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen beta 2-glycoprotein I. Arthritis Rheum. 2011; 63(9): 2774-82
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15)Passam FH, Rahgozar S, Qi M, et al. Redox control of beta 2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1. J Thromb Haemost. 2010; 8(8): 1754-62
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16)Passam FH, Rahgozar S, Qi M, et al. Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood. 2010; 116(11): 1995-7
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17)Charakida M, Besler C, Batuca JR, et al. Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospholipid syndrome. JAMA. 2009; 302(11): 1210-7
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18)Greco TP, Conti-Kelly AM, Anthony JR, et al. Oxidized-LDL/beta(2)-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes. Am J Clin Pathol. 2010; 133(5): 737-43
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21)Bohgaki M, Atsumi T, Yamashita Y, et al. The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta 2 glycoprotein I antibodies. Int Immunol. 2004; 16(11): 1633-41
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22)Oku K, Amengual O, Zigon P, et al. Essential role of the p38 mitogen-activated protein kinase pathway in tissue factor gene expression mediated by the phosphatidylserine-dependent antiprothrombin antibody. Rheumatology (Oxford). 2013; 52(10): 1775-84
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23)Bohgaki M, Matsumoto M, Atsumi T, et al. Plasma gelsolin facilitates interaction between beta 2 glycoprotein I and alpha 5 beta1 integrin. J Cell Mol Med. 2011; 15(1): 141-51
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27)Cohen D, Buurma A, Goemaere NN, et al. Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss. J Pathol. 2011; 225(4): 502-11
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29)Belmont HM, Hopkins P, Edelson HS, et al. Complement activation during systemic lupus erythematosus. C3a and C5a anaphylatoxins circulate during exacerbations of disease. Arthritis Rheum. 1986; 29(9): 1085-9
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30)Canaud G, Kamar N, Anglicheau D, et al. Eculizumab improves posttransplant thrombotic microangiopathy due to antiphospholipid syndrome recurrence but fails to prevent chronic vascular changes. Am Transplant. 2013; 13(8): 2179-85
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31)Lonze BE, Singer AL, Montgomery RA. Eculizu-mab and renal transplantation in a patient with CAPS. N Engl J Med. 2010; 362(18): 1744-5
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