1)Saito A, Pietromonaco S, Loo AK, et al. Complete cloning and sequencing of rat gp330/“megalin,” a distinctive member of the low density lipo-protein receptor gene family. Proc Natl Acad Sci U S A. 1994; 91: 9725-9
|
|
|
2)Saito A, Sato H, Iino N, et al. Molecular mechanisms of receptor-mediated endocytosis in the renal proximal tubular epithelium. J Biomed Biotechnol. 2010; 2010: 403272
|
|
|
3)Shah M, Baterina OY, Jr., Taupin V, et al. ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. J Cell Biol. 2013; 202: 113-27
|
|
|
4)Prabakaran T, Nielsen R, Larsen JV, et al. Receptor-mediated endocytosis of alpha-galactosidase A in human podocytes in Fabry disease. PLoS One. 2011; 6: e25065
|
|
|
5)Tojo A, Onozato ML, Kurihara H, et al. Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats. Hypertens Res. 2003; 26: 413-9
|
|
|
6)Hosojima M, Sato H, Yamamoto K, et al. Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk. Endocrinology. 2009; 150: 871-8
|
|
|
7)Takeyama A, Sato H, Soma-Nagae T, et al. Megalin is downregulated via LPS-TNF-alpha-ERK1/2 signaling pathway in proximal tubule cells. Biochem Biophys Res Commun. 2011; 407: 108-12
|
|
|
8)Schreiber A, Theilig F, Schweda F, et al. Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney. Kidney Int. 2012; 82: 53-9
|
|
|
9)Reisman SA, Chertow GM, Hebbar S, et al. Bardoxolone methyl decreases megalin and activates nrf2 in the kidney. J Am Soc Nephrol. 2012; 23: 1663-73
|
|
|
10)Olson GE, Winfrey VP, Hill KE, et al. Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem. 2008; 283: 6854-60
|
|
|
11)Weyer K, Nielsen R, Petersen SV, et al. Renal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosis. J Nucl Med. 2013; 54: 159-65
|
|
|
12)Matsui I, Hamano T, Mikami S, et al. Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. Am J Physiol Renal Physiol. 2013; 304: F751-60
|
|
|
13)Dagil R, O’Shea C, Nykjaer A, et al. Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin. J Biol Chem. 2013; 288: 4424-35
|
|
|
14)Birn H. The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins. Am J Physiol Renal Physiol. 2006; 291: F22-36
|
|
|
15)Christensen EI, Nielsen R, Birn H. From bowel to kidneys: the role of cubilin in physiology and disease. Nephrol Dial Transplant. 2013; 28: 274-81
|
|
|
16)Boger CA, Chen MH Tin A, et al. CUBN is a gene locus for albuminuria. J Am Soc Nephrol. 2011; 22: 555-70
|
|
|
17)Prabakaran T, Christensen EI, Nielsen R, et al. Cubilin is expressed in rat and human glomerular podocytes. Nephrol Dial Transplant. 2012; 27: 3156-9
|
|
|
18)Hosaka K, Takeda T, Iino N, et al. Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Kidney Int. 2009; 75: 1308-15
|
|
|
19)Koral K, Erkan E. PKB/Akt partners with Dab2 in albumin endocytosis. Am J Physiol Renal Physiol. 2012; 302: F1013-24
|
|
|
20)Tojo A, Endou H. Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol. 1992; 263: F601-6
|
|
|
21)Tanner GA. Glomerular sieving coefficient of serum albumin in the rat: a two-photon microscopy study. Am J Physiol Renal Physiol. 2009; 296: F1258-65
|
|
|
22)Sarav M, Wang Y, Hack BK, et al. Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol. 2009; 20: 1941-52
|
|
|
23)Comper WD, Hilliard LM, Nikolic-Paterson DJ, et al. Disease-dependent mechanisms of albuminuria. Am J Physiol Renal Physiol. 2008; 295: F1589-600
|
|
|
24)Weyer K, Nielsen R, Christensen EI, et al. Generation of urinary albumin fragments does not require proximal tubular uptake. J Am Soc Nephrol. 2012; 23: 591-6
|
|
|
25)Baines RJ, Chana RS, Hall M, et al. CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. Am J Physiol Renal Physiol. 2012; 303: F1006-14
|
|
|
26)Saito A, Kaseda R, Hosojima M et al. Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes. Int J Nephrol. 2010; 2011: 957164
|
|
|
27)Motoyoshi Y, Matsusaka T, Saito A, et al. Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney Int. 2008; 74: 1262-9
|
|
|
28)Theilig F, Kriz W, Jerichow T, et al. Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury. J Am Soc Nephrol. 2007; 18: 1824-34
|
|
|
29)Perkins BA, Rabbani N, Weston A, et al. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes. PLoS One. 2012; 7: e35655
|
|
|
30)Leheste JR, Rolinski B, Vorum H, et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol. 1999; 155: 1361-70
|
|
|
31)Oyama Y, Takeda T, Hama H, et al. Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules. Lab Invest. 2005; 85: 522-31
|
|
|
32)Hvidberg V, Jacobsen C, Strong RK, et al. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett. 2005; 579: 773-7
|
|
|
33)Huang Y, Don-Wauchope AC. The clinical utility of kidney injury molecule 1 in the prediction, diagnosis and prognosis of acute kidney injury: a systematic review. Inflamm Allergy Drug Targets. 2011; 10: 260-71
|
|
|
34)Ogasawara S, Hosojima M, Kaseda R, et al. Significance of urinary full-length and ectodomain forms of megalin in patients with type 2 diabetes. Diabetes Care. 2012; 35: 1112-8
|
|
|
35)Freedman BI, Hicks PJ, Bostrom MA, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int. 2009; 75: 736-45
|
|
|
36)Chasman DI, Fuchsberger C, Pattaro C, et al. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012; 21: 5329-43
|
|
|
37)Tzur S, Rosset S, Shemer R, et al. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Hum Genet. 2010; 128: 345-50
|
|
|
38)Matsusaka T, Niimura F, Shimizu A, et al. Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol. 2012; 23: 1181-9
|
|
|
39)Pergola PE, Raskin P, Toto RD, et al. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med. 2011; 365: 327-36
|
|
|