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2)Tanaka T, Nangaku M. Angiogenesis and hypoxia in the kidney. Nat Rev Nephrol. 2013; 9: 211-22
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3)Ishani A, Xue JL, Himmelfarb J, et al. Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009; 20: 223-8
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6)Krüger B, Krick S, Schröppel B, et al. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A. 2009; 106: 3390-5
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7)Basile DP. The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int. 2007; 72: 151-6
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10)Augustin HG, Koh GY, Alitalo K, et al. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol. 2009; 10: 165-77
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12)Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 2012; 148: 399-408
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13)Rosenberger C, Mandriota S, Eckardt KU, et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol. 2002; 13: 1721-32
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14)Tang N, Wang L, Johnson RS, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 2004; 6: 485-95
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15)Skuli N, Liu L, Keith B, et al. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood. 2009; 114: 469-77
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16)Skuli N, Majmundar AJ, Simon MC, et al. Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest. 2012; 122: 1427-43
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18)Jin J, Sison K, Quaggin SE, et al. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012; 151: 384-99
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19)Lobov IB, Brooks PC, Lang RA. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A. 2002; 99: 11205-10
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20)Kang DH, Joly AH, Johnson RJ, et al. Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol. 2001; 12: 1434-47
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21)Lin SL, Chang FC, Duffield JS, et al. Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol. 2011; 178: 911-23
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22)Basile DP, Zeng P, Yoder MC, et al. Low proliferative potential and impaired angiogenesis of cultured rat kidney endothelial cells. Microcirculation. 2012; 19: 598-609
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23)Chen YT, Chang FC, Lin SL, et al. Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int. 2011; 80: 1170-81
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24)Schrimpf C, Xin C, Duffield JS, et al. Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury. J Am Soc Nephrol. 2012; 23: 868-83
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25)Foo SS, Turner CJ, Adams RH, et al. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell. 2006; 124: 161-73
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27)Kida Y, Ieronimakis N, Duffield JS, et al. EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. J Am Soc Nephrol. 2013; 24: 559-72
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28)Stenzel D, Franco CA, Gerhardt H, et al. Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo. EMBO Rep. 2011; 12: 1135-43
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29)Kang DH, Hughes J, Johnson RJ, et al. Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol. 2001; 12: 1448-57
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30)Kim W, Moon SO, Park SK, et al. COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model. J Am Soc Nephrol. 2006; 17: 2474-83
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31)Gupta R, Tongers J, Losordo DW. Human studies of angiogenic gene therapy. Circ Res. 2009; 105: 724-36
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32)Matsumoto M, Makino Y, Nangaku M, et al. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol. 2003; 14: 1825-32
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33)Tanaka T, Kojima I, Nangaku M, et al. Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model. Lab Invest. 2005; 85: 1292-307
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35)Nangaku M, Tanaka T. Forewarned is forearmed: arm with HIF activation. Nephrol Dial Transplant. 2010; 25: 1385-7
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36)Bernhardt WM, Gottmann U, Eckardt KU, et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009; 106: 21276-81
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37)Sarkar K, Fox-Talbot K, Semenza GL, et al. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci U S A. 2009; 106: 18769-74
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38)Jiang X, Khan MA, Nicolls MR, et al. Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. J Clin Invest. 2011; 121: 2336-49
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39)Kojima I, Tanaka T, Nangaku M, et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol. 2007; 18: 1218-26
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40)Mazzone M, Dettori D, Carmeliet P, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009; 136: 839-51
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