1)Oomura Y, Hori N, Shiraishi T, et al. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides. 2008; 27: 2738-49
|
|
|
2)Drucker DJ, Buse JB, Taylor K, et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet. 2008; 372: 1240-50
|
|
|
3)Blevins T, Pullman J, Malloy J, et al. Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J Clin Endocrinok Metab. 2011; 96: 1301-10
|
|
|
4)Peskin BR, Shcheprov AV, Boye KS, et al. Cardiovascular outcomes associated with a new once-weekly GLP-1 receptor agonist vs. tradition-al therapies for type 2 diabetes: a simulation analysis. Diabetes Obes Metab. 2011; 13: 921-7
|
|
|
5)Astrup A, Rossner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomized, double-blind, placebo-controlled study. Lancet. 2009; 374: 1606-16
|
|
|
6)Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest. 1996; 97: 2152-7
|
|
|
7)Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998; 394: 897-901
|
|
|
8)Shimomura I, Hammer RE, Ikemoto S, et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 1999; 401: 73-6
|
|
|
9)Ebihara K, Kusakabe T, Hirata M, et al. Efficacy and safety of leptin-replacement theraphy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab 2007; 92: 532-41
|
|
|
10)Heymsfield SB, Andrew S, Greenberg MD, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA. 1999; 282: 1568-75
|
|
|
11)Roth JD, Roland BL, Cole RL, et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies. Proc Natl Acad Sci U S A. 2008; 105: 7257-62
|
|
|
12)Gutierrez JA, Solenberg PJ, Perkins DR, et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A. 2008; 105: 6320-5
|
|
|
13)Yang J, Brown MS, Liang G, et al. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008; 132: 387-96
|
|
|
14)Sakata I, Tanaka T, Yamazaki M, et al. Gastric estrogen directly induces ghrelin expression and production in the rat stomach. J Endocrinol. 2006; 190: 749-57
|
|
|
15)Date Y, Shimbara T, Koda S, et al. Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab. 2006; 4: 323-31
|
|
|
16)Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology. 2002; 123: 1120-8
|
|
|
17)Nagaya N, Itoh T, Murakami S, et al. Treatment of cachexia with ghrelin in patients with COPD. Chest. 2005; 128: 1187-93
|
|
|
18)Garcia JM, Friend J, Allen S. Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study. Support Care Cancer. 2012 Jun 16. [Epub ahead of print]
|
|
|
19)Kodama T, Ashitani J, Matsumoto N, et al. Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection. Pulm Pharmacol Ther. 2008; 21: 774-9
|
|
|
20)Lasseter KC, Shaughnessy L, Cummings D, et al. Ghrelin agonist (TZP-101): safety, pharmaco-kinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study. J Clin Pharmacol. 2008; 48: 193-202
|
|
|
21)Bochicchio G, Charlton P, Pezzullo JC, et al. Ghrelin agonist TZP-101/ulimorelin accelerates gastrointestinal recovery independently of opioid use and surgery type: covariate analysis of phase 2 data. World J Surg. 2012; 36: 39-45
|
|
|
22)Barnett BP, Hwang Y, Taylor MS, et al. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science. 2010; 330: 1689
|
|
|