|
1）Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes of BioMedical Research, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007; 316: 1331-6
|
|
|
|
2）Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007; 316: 1336-41
|
|
|
|
|
|
3）Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007; 316: 1341-5
|
|
|
|
|
|
4）Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al. Variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007; 39: 770-5
|
|
|
|
|
5）Miyaki K, Oo T, Song Y, et al. Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorph-ism with elevated hemoglobin A1(c) levels and the prevalence of metabolic syndrome in Japanese men: interaction with dietary energy intake. Am J Epidemiol. 2010; 172: 985-91
|
|
|
|
|
|
6）Stancakova A, Pihlajamäki J, Kuusisto J, et al. Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab. 2008; 93: 1924-30
|
|
|
|
|
|
7）Groenewoud MJ, Dekker JM, Fritsche A, et al. Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia. 2008; 51: 1659-63
|
|
|
|
|
|
8）Okada Y, Kubo M, Ohmiya H, et al. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet. 2012; 44: 302-6
|
|
|
|
|
|
9）Wen W, Cho YS, Zheng W, et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012; 44: 307-11
|
|
|
|
|
|
10）Ching YP, Pang AS, Lam WH, et al. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. J Biol Chem. 2002; 277: 15237-40
|
|
|
|
|
|
11）Wei FY, Nagashima K, Ohshima T, et al. Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med. 2005; 11: 1104-8
|
|
|
|
|
|
12）Wei FY, Suzuki T, Watanabe S, et al. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011; 121: 3598-608
|
|
|
|
|
|
13）Lee KH, Saleh L, Anton BP, et al. Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily. Biochemistry. 2009; 48: 10162-74
|
|
|
|
|
|
14）Arragain S, Garcia-Serres R, Blondin G, et al. Post-translational modification of ribosomal proteins: structural and functional characteriza-tion of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransfer-ase. J Biol Chem. 2010; 285: 5792-801
|
|
|
|
|
|
15）Atta M, Mulliez E, Arragain S, et al. S-Adenosylmethionine-dependent radical-based modification of biological macromolecules. Curr Opin Struct Biol. 2010; 20: 684-92
|
|
|
|
|
|
16）Anantharaman V, Koonin EV, Aravind L. TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. FEMS Microbiol Lett. 2001; 197: 215-21
|
|
|
|
|
|
17）Arragain S, Handelman SK, Forouhar F, et al. Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. J Biol Chem. 2010; 285: 28425-33
|
|
|
|
|
|
18）Jenner LB, Demeshkina N, Yusupova G, et al. Structural aspects of messenger RNA reading frame maintenance by the ribosome. Nat Struct Mol Biol. 2010; 17: 555-60
|
|
|
|
|
|
19）Back SH, Scheuner D, Han J, et al. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009; 10: 13-26
|
|
|
|
|
|
20）Oslowski CM, Urano F. The binary switch between life and death of endoplasmic reticulum-stressed beta cells. Curr Opin Endocrinol Diabetes Obes. 2010; 17: 107-12
|
|
|
|
|
|
21）Scheuner D, Kaufman RJ. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev. 2008; 29: 317-33
|
|
|
|
|