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2)Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastro-enterology. 2011; 140: 124-31
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3)Bhala N, Angulo P, van der Poorten D, et al. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an inter-national collaborative study. Hepatology. 2011; 54: 1208-16
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4)Calori G, Lattuada G, Ragogna F, et al. Fatty liver index and mortality: the Cremona study in the 15th year of follow-up. Hepatology. 2011; 54: 145-52
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5)Ascha MS, Hanouneh IA, Lopez R, et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology. 2010; 51: 1972-8
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6)Valenti L, Al-Serri A, Daly AK, et al. Homo-zygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2010; 51: 1209-17
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7)Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011; 53: 1883-94
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8)Valenti L, Alisi A, Galmozzi E, et al. I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric non-alcoholic fatty liver disease. Hepatology. 2010; 52: 1274-80
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9)Petersen KF, Dufour S, Hariri A, et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med. 2010; 362: 1082-9
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10)Santoro N, Zhang CK, Zhao H, et al. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology. 2012; 55: 781-9
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11)Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology. 2010; 52: 1836-46
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12)Lefterova MI, Lazar MA. New developments in adipogenesis. Trends Endocrinol Metab. 2009; 20(3): 107-14
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13)Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011; 121(6): 2111-7
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14)Holland WL, Bikman BT, Wang LP, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide bio-synthesis in mice. J Clin Invest. 2011; 121(5): 1858-70
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15)Zhang X, Xu A, Chung SK, et al. Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes. 2011; 60(2): 486-95
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16)Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and meta-bolic signals. Nat Rev Mol Cell Biol. 2011; 12(3): 141-51
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17)Misu H, Takamura T, Takayama H, et al. A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 2010; 12(5): 483-95
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18)Miele L, Valenza V, La Torre G, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009; 49(6): 1877-87
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19)Fukada H, Yamashina S, Izumi K, et al. Suppression of autophagy sensitizes Kupffer cells to endotoxin. Hepatol Res. 2012 Apr 10. in press
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20)Younossi ZM, Stepanova M, Rafiq N, et al. Pathologic criteria for nonalcoholic steato-hepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology. 2011; 53(6): 1874-82
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21)Juluri R, Vuppalanchi R, Olson J, et al. Generalizability of the nonalcoholic steato-hepatitis Clinical Research Network histologic scoring system for nonalcoholic fatty liver disease. J Clin Gastroenterol. 2011; 45: 55-8
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22)Feldstein AE, Wieckowska A, Lopez AR, et al. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology. 2009; 50: 1072-8
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23)Musso G, Gambino R, Durazzo M, et al. Noninvasive assessment of liver disease severity with liver fat score and CK-18 in NAFLD: Pro-gnostic value of kiver fat equation goes beyond hepatic gat estimation. Hepatology. 2010; 51(2): 715-7
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24)Park H, lshigami A, Shima T, et al. Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.J Gastroenterol. 2010; 45(4): 426-34
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25)Bell LN, Theodorakis JL, Vuppalanchi R, et al. Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease. Hepatology. 2010; 51: 111-20
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26)Adams LA, Feldstein AE. Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis. J Dig Dis. 2011; 12(1): 10-6
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27)Kayadibi H, Gultepe M, Yasar B, et al. Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease: a surrogate marker to distinguish steatohepatitis from simple steatosis. Dig Dis Sci. 2009; 54: 1764-71
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28)Sumida Y, Yoneda M, Hyogo H, et al. A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease. J Gastroenterol. 2011; 46(2): 257-68
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29)Shah AG, Lydecker A, Murray K, et al. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009; 7: 1104-12
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30)Sumida Y, Yoneda M, Hyogo H, et al. Validatioin of the FIB 4 index in a Japanese nonalcoholic fatty liver disease population. BMC Gastro-enterol. 2012; 12: 2
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31)Abenavoli L, Beaugrand M. Transient elastography in non-alcoholic fatty liver disease. Ann Hepatol. 2012; 11(2): 172-8
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32)Friedrich-Rust M, Romen D, Vermehren J, et al. Acoustic radiation force impulse-imaging and transient elastography for non-invasive assess-ment of liver fibrosis and steatosis in NAFLD. Eur J Radiol. 2012; 81(3): e325-31
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33)Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010; 51: 121-9
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34)Johnson NA, George J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology. 2010; 52(1): 370-81
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35)Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for non-alcoholic steatohepatitis. N Engl J Med. 2010; 362: 1675-85
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36)Lavine JE, Schwimmer JB, Van Natta ML, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA. 2011; 305: 1659-68
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37)Torres DM, Jones FJ, Shaw JC, et al. Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial. Hepatology. 2011; 54(5): 1631-9
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38)Leuschner UF, Lindenthal B, Herrmann G, et al. High-dose ursodeoxycholic acid therapy for non-alcoholic steatohepatitis: a double-blind,randmized,placebo-controlled trial.Hepatology. 2010; 52: 472-9
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39)Pathil A, Mueller J, Warth A, et al. Ursodeoxycholyl lysophosphatidylethanolamide improves steatosis and inflammation in murine models of nonalcoholic fatty liver disease. Hepatology. 2012; 55(5): 1369-78
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40)Zein CO, Yerian LM, Gogate P, et al. Pent-oxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology. 2011; 54: 1610-9
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41)Zein CO, Lopez R, Kirwan JP, et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism. Hepatology 2012; 56(4): 1291-9
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