| 
									
									1)Von Minckwitz G, du Bois A, Schmidt M, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study. J Clin Oncol. 2009; 27: 1999-2006
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									2)Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010; 28: 1124-30
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									3)Arnold D, Andre T, Bennouna J, et al. Bevacizumab(BEV)plus chemotherapy(CT)continued beyond first progression in patients with metastatic colorectal cancer(mCRC)previously treated with BEV plus CT: Results of a randomized phase III intergroup study(TML study). J Clin Oncol. 2012; 30: abstr CRA3503
								 | 
							
							
								| 
									
									
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									4)Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline(version 1.1). Eur J Cancer. 2009; 45: 228-47
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									5)Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study(BRiTE). J Clin Oncol. 2008; 26: 5326-34
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									6)Shukuya T, Takahashi T, Tamiya A, et al. Gefitinib plus paclitaxel after failure of gefitinib in non-small cell lung cancer initially responding to gefitinib. Anticancer Res. 2009; 29: 2747-51
								 | 
							
							
								
									
									 
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									7)Balak MN, Gong Y, Riely GJ, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006; 12: 6494-501
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									8)Jackman DM, Holmes AJ, Lindeman N, et al. Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib. J Clin Oncol. 2006; 24: 4517-20
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									9)Shukuya T, Takahashi T, Naito T, et al. Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure. Lung Cancer. 2011; 74(3): 457-61
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									10)Inomata M, Shukuya T, Takahashi T, et al. Continuous administration of EGFR-TKIs following radiotherapy after disease progression in bone lesions for non-small-cell lung cancer. Anticancer Res. 2011; 31: 4519-23
								 | 
							
							
								
									
									 
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									11)Weickhardt AJ, Scheier B, Burke JM, et al. Continuation of EGFR/ALK inhibition after local therapy of oligoprogressive disease in EGFR mutant (Mt) and ALK+ non-small cell lung cancer (NSCLC). J Clin Oncol. 2012; 30: abstr 7526
								 | 
							
							
								| 
									
									
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									12)http://clinicaltrials.gov, NCT01544179
								 | 
							
							
								| 
									
									
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									13)http://clinicaltrials.gov, NCT01310036
								 | 
							
							
								| 
									
									
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									14)Gridelli C, Bennouna J, de Castro J, et al. Randomized phase IIIb trial evaluating the continuation of bevacizumab beyond disease progression in patients with advanced non-squamous non-small-cell lung cancer after first-line treatment with bevacizumab plus platinum-based chemotherapy: treatment rationale and protocol dynamics of the AvaALL (MO22097) trial. Clin Lung Cancer. 2011; 12(6): 407-11
								 | 
							
							
								
									
									 
									 
									
									
									
									
									
									
								 | 
							
							
								
									 
								 | 
							
						
							
								| 
									
									15)Takeda M, Okamoto I, Yamanaka T. Impact of treatment with bevacizumab beyond disease progression: a randomized phase II study of docetaxel with or without bevacizumab after platinum-based chemotherapy plus bevacizumab in patients with advanced nonsquamous non–small cell lung cancer (WJOG 5910L) BMC. Cancer. 2012; 12(1): 327
								 | 
							
							
								
									
									 
									
									
									
									
									
									
									
								 | 
							
							
								
									 
								 |