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8)Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained rece­ptor blockade and good antitumor efficacy. Can­cer Res. 2008; 68(12): 4774-82
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23)Stopfer P, Rathgen K, Bischoff D, et al. Phar­macokinetics and metabo­lism of BIBF 1120 after oral dosing to healthy male volunteers. Xeno­biotica. 2011; 41(4): 297-311
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25)Mross KB, Gmehling D, Frost A, et al. A clinical, phase I pharmacokinetic (PK) and pharmacody­namics study of twice-daily BIBF 1120 in advanced cancer patients. J Clin Oncol. 2005; 23: 3031
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26)Okamoto I, Kaneda H, Satoh T, et al. 2010. Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhi­bitor in patients with advanced solid tumors. Mol Cancer Ther. 2010; 9(10): 2825-33
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27)du Bois A, Huober J, Stopfer P, et al. A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and car­bop­latin in patients with advanced gynecological malignancies. Ann Oncol. 2010; 21(2): 370-5
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28)Bousquet G, Alexandre J, Le Tourneau C, et al. Phase I study of BIBF 1120 with docetaxel and prednisone in metastatic chemo-naive hormone-refractory prostate cancer patients. Br J Cancer. 2011; 105: 1640-5
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29)Ellis PM, Kaiser R, Zhao Y, et al. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemet­rexed in pretreated non–small cell lung cancer patients. Clin Cancer Res. 2010; 16: 2881-9
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30)Reck M, Kaiser R, Eschbach C, et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhi­bitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol. 2011; 22: 1374-81
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31)吾妻安良太,谷口博之,井上義一,他.日本人IPFにおけるBIBF1120(B)とPirfenidone(P)併用投与の安全性,忍容性,薬物動態を検討する臨床試験 第52回呼吸器学会総会発表.日呼吸誌.2012; 1: 125
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32)Herbst RS. Toxicities of antiangiogenic therapy in nonsmall-cell lung cancer. Clin Lung Cancer. 2006; 8 Suppl 1: S23-30
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33)ClinicalTrials.gov. LUME-Lung 1: BIBF 1120 plus­docetaxel as compared to placebo plus docetaxel in 2nd line non small cell lung cancer. 2008. Avail­able from: http://clinicaltrials.gov/ct2/show/NCT00805194? term=BIBF+1120&rank=6. Acce­ssed October 5, 2012
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34)ClinicalTrials.gov. LUME-Lung 2: BIBF 1120 plus pemetrexed compared to placebo plus pemetrexed in 2nd line nonsquamous NSCLC. 2008. Avail­able from: http://clinicaltrials.gov/ct2/show/NCT00806819?intr=%22BIBF++1120%22&phase=2&rank=1. Accessed October 5, 2012
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35)ClinicalTrials.gov. Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibro­sis Patients 2011. Available from: http://clinical­trials.gov/ct2/show/NCT01335464?intr=%22BIBF++1120%22&phase=2&rank=3. Accessed October 5, 2012
医中誌リンクサービス
36)ClinicalTrials. gov. Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibro­sis PatientsⅡ 2011. Available from: http://clinical­trials.gov/ct2/show/NCT01335477?intr=%22BIBF++1120%22&phase=2&rank=4. Accessed October 5, 2012
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