|
1）Jiang Y, Dunbar A, Gondek LP, et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood. 2009; 113: 1315-25
|
|
|
|
2）Figueroa ML, Lugthart S, Li Y, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 2010; 17: 13-27
|
|
|
|
|
|
3）di Croce L, Raker VA, Corsaro M, et al. Methyl-transferase recruitment and DNA hypermethyl-ation of target promoters by an oncogenic transcription factor. Science. 2002; 295: 1079-82
|
|
|
|
|
|
4）Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010; 363: 2424-33
|
|
|
|
|
|
5）Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyl-transferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011; 43: 309-15
|
|
|
|
|
|
6）Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009; 360: 2289-301
|
|
|
|
|
|
7）Aimiuwu J, Wang H, Chen P, et al. RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia. Blood. 2012; 119: 5229-38
|
|
|
|
|
|
8）Okada Y, Feng Q, Lin Y, et al. HDOT1L links histone methylation to leukemogenesis. Cell. 2005; 121: 167-78
|
|
|
|
|
|
9）Bernt KM, Zhu N, Sinha AU, et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 2011; 20: 66-78
|
|
|
|
|
|
10）Daigle SR, Olhava EJ, Therkelsen CA, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011; 20: 53-65
|
|
|
|
|
|
11）Neff T, Sinha AU, Kluk MJ, et al. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A. 2012; 109: 5028-33
|
|
|
|
|
|
12）Zuber J, Shi J, Wang E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia. Nature. 2011; 478: 524-8
|
|
|
|
|
|
13）Dawson MA, Prinjha RK, Dittmann A, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011; 478: 529-33
|
|
|
|
|
|
14）Schenk T, Chen WC, Gollner S, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012; 18: 605-11
|
|
|
|
|