1)Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell. 2008; 132(4): 681-96
|
|
|
2)Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007; 8(9): 703-13
|
|
|
3)Lombard DB, Chua KF, Mostoslavsky R, et al. DNA repair, genome stability, and aging. Cell. 2005; 120(4): 497-512
|
|
|
4)Garinis GA, van der Horst GT, Vijg J, et al. DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol. 2008; 10(11): 1241-7
|
|
|
5)Nijnik A, Woodbine L, Marchetti C, et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature. 2007; 447(7145): 686-90
|
|
|
6)Rossi DJ, Bryder D, Seita J, et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007; 447(7145): 725-9
|
|
|
7)Garinis GA, van der Horst GT, Vijg J, et al. DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol. 2008; 10(11): 1241-7
|
|
|
8)Ruube CE, Fricke A, Widmann TA, et al. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS One. 2011; 6(3): e17487
|
|
|
9)Ripperger T, Beger C, Rahner N, et al. Constitutional mismatch repair deficiency and childhood leukemia/lymphoma-report on a novel biallelic MSH6 mutation. Haematologica. 2010; 95(5): 841-4
|
|
|
10)Kenyon J, Fu P, Lingas K, et al. Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 2012; 120(16): 3229-36
|
|
|
11)Vaish M. Mismatch repair deficiencies trans-forming stem cells into cancer stem cells and therapeutic implications. Mol Cancer. 2007; 6: 26
|
|
|
12)Branzei D, Foiani M. Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol. 2010; 11(3): 208-19
|
|
|
13)Mohrin M, Bourke E, Alexander D, et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell. 2010; 7(2): 174-85
|
|
|
14)Milyavsky M, Gan OI, Trottier M, et al. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell. 2010; 7(2): 186-97
|
|
|
15)Shao L, Feng W, Lee KJ, et al. A sensitive and quantitative polymerase chain reaction-based cell free in vitro non-homologous end joining assay for hematopoietic stem cells. PLoS One. 2012; 7(3): e33499
|
|
|
16)Kobayashi CI, Suda T. Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol. 2012; 227(2): 421-30
|
|
|
17)Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 2011; 9(4): 298-310
|
|
|
18)Ito K, Hirao A, Arai F, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature. 2004; 431(7011): 997-1002
|
|
|
19)Ito K, Hirao A, Arai F, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med. 2006; 12(4): 446-51
|
|
|
20)Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007; 128(2): 325-39
|
|
|
21)Miyamoto K, Araki KY, Naka K, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 2007; 1(1): 101-12
|
|
|
22)Yahata T, Takanashi T, Muguruma Y, et al. Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hemato-poietic stem cells. Blood. 2011; 118(11): 2941-50
|
|
|
23)Lansdorp PM. Telomeres, stem cells, and hematology. Blood. 2008; 111(4): 1759-66
|
|
|
24)Nitta E, Yamashita M, Hosokawa K, et al. Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-indepen-dent mechanism. Blood. 2011; 117(16): 4169-80
|
|
|
25)Sokolov MV, Dickey JS, Bonner WM, et al. gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication. Cell Cycle. 2007; 6(18): 2210-2
|
|
|
26)Wang C, Jurk D, Maddick M, et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell. 2009; 8(3): 311-23
|
|
|
27)Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007; 130(2): 223-33
|
|
|
28)Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science. 2008; 319(5868): 1352-5
|
|
|
29)Horibe S, Takagi M, Unno J, et al. DNA damage check points prevent leukemic transformation in myelodysplastic syndrome. Leukemia. 2007; 21(10): 2195-8
|
|
|
30)Bocker MT, Hellwig I, Breiling A, et al. Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood. 2011; 117(19): e182-9
|
|
|
31)Norddahl GL, Pronk CJ, Wahlestedt M, et al. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell. 2011; 8(5): 499-510
|
|
|
32)Wang J, Sun Q, Morita Y, et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell. 2012; 148(5): 1001-14
|
|
|
33)Viale A, De Franco F, Orleth A, et al. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature. 2009; 457(7225): 51-6
|
|
|
34)Ceccaldi R, Parmar K, Mouly E, et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell. 2012; 11(1): 36-49
|
|
|
35)Raaijmakers MH. Myelodysplastic syndromes: revisiting the role of the bone marrow micro-environment in disease pathogenesis. Int J Hematol. 2012; 95(1): 17-25
|
|
|