|
1）Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998; 282: 1145-7
|
|
|
|
2）Takahashi K, Yamanaka S. Induction of pluri-potent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126: 663-76
|
|
|
|
|
3）Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131: 861-72
|
|
|
|
|
|
4）Yazawa M, Hsueh B, Jia X, et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature. 2011; 471: 230-4
|
|
|
|
|
|
5）Keating MT. The long QT syndrome. A review of recent molecular genetic and physiologic discoveries. Medicine (Baltimore). 1996; 75: 1-5
|
|
|
|
|
|
6）Roden DM, Lazzara R, Rosen M, et al. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circu-lation. 1996; 94: 1996-2012
|
|
|
|
|
|
7）Splawski I, Timothy KW, Sharpe LM, et al. Ca(V) 1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell. 2004; 119: 19-31
|
|
|
|
|
|
8）Pasca SP, Portmann T, Voineagu I, et al. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med. 2011; 17: 1657-62
|
|
|
|
|
|
9）Okita K, Matsumura Y, Sato Y, et al. A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011; 8: 409-12
|
|
|
|
|
|
10）Yarotskyy V, Elmslie KS. Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (CaV1.2) Ca21 channels. Br J Pharmacol. 2007; 152: 386-95
|
|
|
|
|
|
11）Moretti A, Bellin M, Welling A, et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med. 2010; 363: 1397-409
|
|
|
|
|
|
12）Itzhaki I, Maizels L, Huber I, et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature. 2011; 471: 225-9
|
|
|
|
|
|
13）Meijer L, Borgne A, Mulner O, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 1997; 243: 527-36
|
|
|
|
|
|
14）Sun N, Yazawa M, Liu J, et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med. 2012; 4: 130ra47
|
|
|
|
|