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9)Song J, Hu X, Riazi S, et al. Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats. Am J Physiol Renal Physiol. 2006; 290: F1055-64
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10)Zhang YH, Alvarez de la Rosa D, Canessa CM, et al. Insulin- induced phosphorylation of ENaC correlates with increased sodium channel function in A6 cells. Am J Physiol Cell Physiol. 2005; 288: C141-7
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12)Ohta A, Rai T, Yui N, et al. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009; 18: 3978-86
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13)Yang SS, Morimoto T, Rai T, et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007; 5: 331-44
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14)Chiga M, Rafiqi FH, Alessi DR, et al. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci. 2011; 124(Pt 9): 1391-5
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15)Castaneda-Bueno M, Cervantes-Perez LG, Vazquez N, et al. Activation of the renal Na+: Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A. 2012; 109: 7929-34
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16)Khan HM, Sohara E, Ohta A, et al. Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination. Biochem Biophys Res Commun. 2012; 425: 456-61
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17)Chiga M, Rai T, Yang SS, et al. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int. 2008; 74: 1403-9
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18)Naito S, Ohta A, Sohara E, et al. Regulation of WNK1 kinase by extracellular potassium. Clin Exp Nephrol. 2011; 15: 195-202
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19)Talati G, Ohta A, Rai T, et al. Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun. 2010; 393: 844-8
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20)Sohara E, Rai T, Yang SS, et al. Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One. 2011; 6: e24277
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21)Nishida H, Sohara E, Nomura N, et al. PI3K/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension. 2012; 60: 981-90
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22)Komers R, Rogers S, Oyama TT, et al. Enhanced phosphorylation of Na-Cl cotransporter in experimental metabolic syndrome - role of insulin. Clin Sci. 2012; 123: 635-47
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23)Susa K, Kita S, Iwamoto T, et al. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. Clin Exp Nephrol. 2012; 16: 530-8
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