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2) Yu CE, Oshima J, Fu YH, et al. Positional cloning of the Wernerʼs syndrome gene. Science. 1996; 272: 258-62
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3) Goto M, Rubenstein M, Weber J, et al. Genetic linkage of Wernerʼs syndrome to five markers on chromosome 8. Nature. 1992; 355: 735-8
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4) Matsumoto T, Imamura O, Yamabe Y, et al. Mutation and haplotype analyses of the Wernerʼs syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population. Hum Genet. 1997; 100: 123-30
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5) Satoh M, Imai M, Sugimoto M, et al. Prevalence of Wernerʼs syndrome heterozygotes in Japan. Lancet. 1999; 353: 1766
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6) Huang S, Li B, Gray MD, et al. The premature ageing syndrome protein, WRN, is a 3ʼ->5ʼ exonuclease. Nat Genet. 1998; 20: 114-6
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8) Kusumoto R, Dawut L, Marchetti C, et al. Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. Biochemistry. 2008; 47: 7548-56
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9) Harrigan JA, Wilson DM 3rd, Prasad R, et al. The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res. 2006; 34: 745-54
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10) Lebel M, Spillare EA, Harris CC, et al. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem. 1999; 274: 37795-9
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11) Otterlei M, Bruheim P, Ahn B, et al. Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci. 2006; 119: 5137-46
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12) Cheng WH, von Kobbe C, Opresko PL, et al. Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem. 2004; 279: 21169-76
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13) Li B, Navarro S, Kasahara N, et al. Identification and biochemical characterization of a Wernerʼs syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 2004; 279: 13659-67
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14) Salk D, Au K, Hoehn H, et al. Cytogenetics of Wernerʼs syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet. 1981; 30: 92-107
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15) Ogburn CE, Oshima J, Poot M, et al. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet. 1997; 101: 121-5
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16) Pichierri P, Rosselli F, Franchitto A. Wernerʼs syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene. 2003; 22: 1491-500
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17) Crabbe L, Jauch A, Naeger CM, et al. Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci U S A. 2007; 104: 2205-10
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18) Chang S, Multani AS, Cabrera NG, et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. 2004; 36: 877-82
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19) Opresko PL. Telomere ResQue and preservation-roles for the Werner syndrome protein and other RecQ helicases. Mech Ageing Dev. 2008; 129: 79-90
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20) Mostoslavsky R, Chua KF, Lombard DB, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006; 124: 315-29
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21) Michishita E, McCord RA, Berber E, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008; 452: 492-6
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22) Yokote K, Honjo S, Kobayashi K, et al. Metabolic improvement and abdominal fat redistribution in Werner syndrome by pioglitazone. J Am Geriatr Soc. 2004; 52: 1582-3
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23) Honjo S, Yokote K, Fujishiro T, et al. Early amelioration of insulin resistance and reduction of interleukin-6 in Werner syndrome using pioglitazone. J Am Geriatr Soc. 2008; 56: 173-4
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24) Goto M, Matsuura M. Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome. Biosci Trends. 2008; 2: 81-7
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25) Yokote K, Saito Y. Extension of the life span in patients with Werner syndrome. J Am Geriatr Soc. 2008; 56: 1770-1
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26) Ohnishi S, Fujimoto M, Oide T, et al. Primary lung cancer associated with Werner syndrome. Geriatr Gerontol Int. 2010; 10: 319-23
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27) Honjo S, Yokote K, Takada A, et al. Etidronate ameliorates painful soft-tissue calcification in Werner syndrome. J Am Geriatr Soc. 2005; 53: 2038-9
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28) Honjo S, Yokote K, Fujimoto M, et al. Clinical outcome and mechanism of soft tissue calcification in Werner syndrome. Rejuvenation Res. 2008; 11: 809-19
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29) Davis T, Bachler MA, Wyllie FS, et al. Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. Ann N Y Acad Sci. 2010; 1197: 45-8
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30) Bagley MC, Davis T, Rokicki MJ, et al. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Med Chem. 2010; 2: 193-201
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31) Massip L, Garand C, Paquet ER, et al. Vitamin C restores healthy aging in a mouse model for Werner syndrome. FASEB J. 2010; 24: 158-72
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32) Liu GH, Barkho BZ, Ruiz S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011; 472: 221-5
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