文献リスト

1) 浦野文彦. 小胞体ストレスと膵β細胞の機能. 生化学. 2007; 79: 1055-9

2) 親泊政一. 小胞体: 小胞体ストレスと糖尿病. Dia­betes Frontire. 2009; 20: 715-20

3) Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type2 diabetes. Science. 2004; 306: 457-61

4) Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006; 313: 1137-40

5) Xiao C, Giacca A, Lewis GF. Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. Diabetes. 2011; 60: 918-24

6) Yoshioka M, Kayo T, Ikeda A, et al. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes. 1997; 46: 887–94

7) Meur G, Simon A, Harun N, et al. Insulin gene mutations resulting in early-onset diabetes: Marked Differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes. 2010; 59: 653-61

8) Lipson KL, Fonseca SG, Ishigaki S, et al. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab. 2006; 4: 245-54

9) Allagnat F, Christulia F, Ortis F, et al. Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. Diabetologia. 2010; 53: 1120-30

10) Gwiazda KS, Yang TL, Lin Y, et al. Effects of palmitate on ER and cytosolic Ca2＋ homeostasis in beta-cells. Am J Physiol Endocrinol Metab. 2009; 296: E690-701

11) Preston AM, Gurisik E, Bartley C, et al. Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia. 2009; 52: 2369-73

12) Giacca A, Xiao C, Oprescu AI, et al. Lipid-induced pancreatic β-cell dysfunction: focus on in vivo study. Am J Physiol Endocrinol Metab. 2011; 300: E255-62

13) Tanabe K, Liu Y, Hasan SD, et al. Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. Plos ONE. 2011; 6: e18146-65

14) Asahara S, Matsuda T, Kido Y, et al. Increased ribosomal biogenesis induces pancreatic beta cell failure in mice model of type 2 diabetes. Biochem Biophys Res Commun. 2009; 381: 367-71

15) Scheuner D, Vander Mierde D, Song B, et al. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med. 2005; 11: 757-64

16) Oyadomari S, Takeda K, Takiguchi M, et al. Nitric oxide-induced apotosis in pancreatic β-cells is mediated by the endplasmic reticulum stress pathway. Proc Natl Acad Sci U S A. 2001; 98: 10845-50

17) Tu BP, Weissman JS. Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol. 2004; 164: 341-6

18) Kaufman RJ, Back SH, Song B, et al. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab. 2010; 12: 99-107

19) Matveyenko AV, Gurlo T, Daval M, et al. Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. Diabetes. 2009; 58: 906-16

20) Xue X, Piao JH, Nakajima A, et al. Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem. 2005; 280: 33917-25

21) Lee JW, Kim WH, Yeo J, et al. ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells. Mol Cells. 2010; 30: 545-9

22) Srinivasan S, Ohsugi M, Liu Z, et al. Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells. Diabetes. 2005; 54: 968-75

23) Park SW, Zhou Y, Lee J, et al. The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation. Nat Med. 2010; 16: 429-37

24) Winnay JN, Boucher J, Mori MA, et al. A regulatory subunit of phosphoinositide 3 kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med. 2010; 16: 438-45

25) Matsuda T, Kido Y, Uchida T, et al. Reduced insulin signaling and endoplasmic reticulum stress act synergistically to deteriorate pancreatic beta cell function. Kobe J Med Sci. 2008; 18: E114-21

26) Liew CW, Bochenski J, Kawamori D, et al. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010; 120: 2876-88

27) Delepine M, Nicolino M, Barrett T, et al. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet. 2000; 25: 406-9

28) Harding HP, Zeng H, Zhang Y, et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell. 2001; 7: 1153-63

29) Sandhu MS, Weedon MN, Fawcett KA, et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet. 2007; 39: 951-3

30) Fonseca SG, Ishigaki S, Oslowski CM, et al. Wolfram syndrome 1 gene negatively regurates ER stress signaling in rodent and human cells. J Clin Invest. 2010; 120: 744-55

31) Oslowski CM, Urano F. The binary switch that controls the life and death decisions of ER stressed β cells. Current Opinion in Cell Biology. 2010; 23: 1-9

32) Matsuda T, Kido Y, Kasuga M, et al. Ablation of C/EBPβ alleviates ER stress and pancreaticβ cell failure through the GRP78 chaperone in mice. J Clin Invest. 2010; 120: 115-26

33) Hui H, Nourparvar A, Zhao X, et al. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5ʼ-adenosine mono-phosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology. 2003; 144: 1444-55

34) Brissova M, Shiota M, Nicholson WE, et al. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem. 2002; 277: 11225-32

35) Johnson JD, Ahmed NT, Luciani DS, et al. Increased islet apoptosis in Pdx1＋/- mice. J Clin Invest. 2003; 111: 1147-60

36) Wang H, Kouri G, Wollheim CB. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J Cell Sci. 2005; 118: 3905-15

37) Li Y, Cao X, Li LX, et al. beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes. 2005; 54: 482-91

38) Sachdeva MM, Claiborn KC, Khoo C, et al. Pdx1 (MODY4) regulates pancreatic beta cell suscep-tibility to ER stress. Proc Natl Acad Sci U S A. 2009; 106: 19090-5

39) Yusta B, Baggio LL, Estall JL, et al. GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress. Cell metab. 2006; 4: 391-406

40) Cunha DA, Ladriere L, Ortis F, et al. GLP-1 agonists protect pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upre-gulation of BiP and JunB. Diabetes, 2009; 58: 2851-62

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