1) Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimerʼs disease: recommendations from the National Institute on Aging-Alzheimerʼs Association work-groups on diagnostic guidelines for Alzheimerʼs disease. Alzheimers Dement. 2011; 7: 280-92
|
|
|
2) Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimerʼs disease with Pittsburgh Compound-B. Ann Neurol. 2004; 55: 306-19
|
|
|
3) Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimerʼs disease. Brain. 2008; 131(Pt 6): 1630-45
|
|
|
4) Leinonen V, Alafuzoff I, Aalto S, et al. Assess-ment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomo-graphy with carbon 11-labeled Pittsburgh Com-pound B. Arch Neurol. 2008; 65: 1304-9
|
|
|
5) Rinne JO, Brooks DJ, Rossor MN, et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimerʼs disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol. 2010; 9: 363-72
|
|
|
6) Cairns NJ, Ikonomovic MD, Benzinger T, et al. Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report. Arch Neurol. 2009; 66: 1557-62
|
|
|
7) Bao F, Wicklund L, Lacor PN, et al. Different beta-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiol Aging. 2011 Jun 15
|
|
|
8) Klunk WE, Price JC, Mathis CA, et al. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J Neurosci. 2007; 27: 6174-84
|
|
|
9) Koivunen J, Verkkoniemi A, Aalto S, et al. PET amyloid ligand [11C]PIB uptake shows predomi-nantly striatal increase in variant Alzheimerʼs disease. Brain. 2008; 131(Pt 7): 1845-53
|
|
|
10) Villemagne VL, Ataka S, Mizuno T, et al. High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types. Arch Neurol. 2009; 66: 1537-44
|
|
|
11) Villemagne VL, Pike KE, Chetelat G, et al. Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease. Ann Neurol. 2011; 69: 181-92
|
|
|
12) Wolk DA, Price JC, Saxton JA, et al. Amyloid imaging in mild cognitive impairment subtypes. Ann Neurol. 2009; 65: 557-68
|
|
|
13) Tolboom N, Yaqub M, van der Flier WM, et al. Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET. J Nucl Med. 2009; 50: 191-7
|
|
|
14) Dubois B, Feldman HH, Jacova C, et al. Revising the definition of Alzheimerʼs disease: a new lexicon. Lancet Neurol. 2010; 9: 1118-27
|
|
|
15) Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimerʼs disease: recommendations from the National Institute on Aging-Alzheimerʼs Asso-ciation workgroups on diagnostic guidelines for Alzheimerʼs disease. Alzheimers Dement. 2011; 7: 270-9
|
|
|
16) Okello A, Koivunen J, Edison P, et al. Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. Neurology. 2009; 73: 754-60
|
|
|
17) Koivunen J, Scheinin N, Virta JR, et al. Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study. Neurology. 2011; 76: 1085-90
|
|
|
18) Mintun MA, Larossa GN, Sheline YI, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006; 67: 446-52
|
|
|
19) Hatashita S, Yamasaki H. Clinically different stages of Alzheimerʼs disease associated by amyloid deposition with [11C]-PIB PET imaging. J Alzheimers Dis. 2010; 21: 995-1003
|
|
|
20) Morris JC, Roe CM, Xiong C, et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol. 2010; 67: 122-31
|
|
|
21) Resnick SM, Sojkova J, Zhou Y, et al. Longitu-dinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology. 2010; 74: 807-15
|
|
|
22) Drzezga A, Grimmer T, Henriksen G, et al. Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. Neurology. 2009; 72: 1487-94
|
|
|
23) Reiman EM, Chen K, Liu X, et al. Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimerʼs disease. Proc Natl Acad Sci U S A. 2009; 106: 6820-5
|
|
|
24) Morishima-Kawashima M, Oshima N, Ogata H, et al. Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumu-lation in the human brain. Am J Pathol. 2000; 157: 2093-9
|
|
|
25) Fagan AM, Mintun MA, Mach RH, et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006; 59: 512-9
|
|
|
26) Fagan AM, Mintun MA, Shah AR, et al. Cerebro-spinal fluid tau and ptau(181) increase with cor-tical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimerʼs disease. EMBO Mol Med. 2009; 1: 371-80
|
|
|
27) Ances BM, Christensen JJ, Teshome M, et al. Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study. Neurology. 2010; 75: 111-5
|
|
|
28) Sojkova J, Zhou Y, An Y, et al. Longitudinal patterns of beta-amyloid deposition in non-demented older adults. Arch Neurol. 2011; 68: 644-9
|
|
|
29) Kadir A, Almkvist O, Forsberg A, et al. Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimerʼs disease. Neurobiol Aging. 2010 Aug 3
|
|
|
30) Scheinin NM, Aalto S, Koikkalainen J, et al. Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. Neurology. 2009; 73: 1186-92
|
|
|
31) Grimmer T, Tholen S, Yousefi BH, et al. Progression of cerebral amyloid load is asso-ciated with the apolipoprotein E epsilon4 geno-type in Alzheimerʼs disease. Biol Psychiatry. 2010; 68: 879-84
|
|
|
32) Chételat G, Villemagne VL, Bourgeat P, et al. Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Ann Neurol. 2010; 67: 317-24
|
|
|
33) Becker JA, Hedden T, Carmasin J, et al. Amyloid-beta associated cortical thinning in clinically normal elderly. Ann Neurol. 2011; 69: 1032-42
|
|
|
34) Sheline YI, Raichle ME, Snyder AZ, et al. Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol Psychiatry. 2010; 67: 584-7
|
|
|
35) Morris JC, Roe CM, Grant EA, et al. Pittsburgh compound B imaging and prediction of progres-sion from cognitive normality to symptomatic Alzheimer disease. Arch Neurol. 2009; 66: 1469-75
|
|
|
36) Roe CM, Mintun MA, Ghoshal N, et al. Alzheimer disease identification using amyloid imaging and reserve variables: proof of concept. Neurology. 2010; 75: 42-8
|
|
|
37) Kemppainen NM, Aalto S, Karrasch M, et al. Cognitive reserve hypothesis: Pittsburgh Com-pound B and fluorodeoxyglucose positron emis-sion tomography in relation to education in mild Alzheimerʼs disease. Ann Neurol. 2008; 63: 112-8
|
|
|
38) Roe CM, Mintun MA, DʼAngelo G, et al. Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. Arch Neurol. 2008; 65: 1467-71
|
|
|
39) Rentz DM, Locascio JJ, Becker JA, et al. Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol. 2010; 67: 353-64
|
|
|
40) Landt J, DʼAbrera JC, Holland AJ, et al. Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar {beta}-amyloid in adults with down syndrome: safety, acceptability, and feasibility. Arch Neurol. 2011; 68: 890-6
|
|
|
41) Johnson KA, Gregas M, Becker JA, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol. 2007; 62: 229-34
|
|
|
42) Engler H, Santillo AF, Wang SX, et al. In vivo amyloid imaging with PET in frontotemporal dementia. Eur J Nucl Med Mol Imaging. 2008; 35: 100-6
|
|
|
43) Rabinovici GD, Jagust WJ, Furst AJ, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol. 2008; 64: 388-401
|
|
|
44) Villemagne VL, McLean CA, Reardon K, et al. 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2009; 80: 998-1001
|
|
|
45) Hyare H, Ramlackhansingh A, Gelosa G, et al. 11C-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2011 Apr 8
|
|
|
46) Edison P, Rowe CC, Rinne JO, et al. Amyloid load in Parkinsonʼs disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry. 2008; 79: 1331-8
|
|
|
47) Burack MA, Hartlein J, Flores HP, et al. In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology. 2010; 74: 77-84
|
|
|
48) Kantarci K, Yang C, Schneider JA, et al. Ante mortem amyloid imaging and beta-amyloid pathology in a case with dementia with Lewy bodies. Neurobiol Aging. 2010 Oct 18
|
|
|
49) Villemagne VL, Pike K, Pejoska S, et al. 11C-PiB PET ABri imaging in Worster-Drought syndrome (familial British dementia): a case report. J Alzheimers Dis. 2010; 19: 423-8
|
|
|
50) Fodero-Tavoletti MT, Rowe CC, McLean CA, et al. Characterization of PiB binding to white matter in Alzheimer disease and other dementias. J Nucl Med. 2009; 50: 198-204
|
|
|
51) Stankoff B, Freeman L, Aigrot MS, et al. Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-(1)(1)C]-2-(4ʼ-methylaminophenyl)- 6-hydroxybenzothiazole. Ann Neurol. 2011; 69: 673-80
|
|
|
52) Kadir A, Nordberg A. Target-specific PET probes for neurodegenerative disorders related to dementia. J Nucl Med. 2010; 51: 1418-30
|
|
|
53) Kudo Y, Okamura N, Furumoto S, et al. 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimerʼs disease patients. J Nucl Med. 2007; 48: 553-61
|
|
|
54) Furukawa K, Okamura N, Tashiro M, et al. Amyloid PET in mild cognitive impairment and Alzheimerʼs disease with BF-227: comparison to FDG-PET. J Neurol. 2010; 257: 721-7
|
|
|
55) Waragai M, Okamura N, Furukawa K, et al. Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimerʼs disease. J Neurol Sci. 2009; 285: 100-8
|
|
|
56) Shao H, Okamura N, Sugi K, et al. Voxel-based analysis of amyloid positron emission tomo-graphy probe [C]BF-227 uptake in mild cognitive impairment and alzheimerʼs disease. Dementia Geriatr Cogn Disord. 2010; 30: 101-11
|
|
|
57) Fodero-Tavoletti MT, Mulligan RS, Okamura N, et al. In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies. Eur J Pharmacol. 2009; 617(1-3): 54-8
|
|
|
58) Kikuchi A, Takeda A, Okamura N, et al. In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy. Brain. 2010; 133(Pt 6): 1772-8
|
|
|
59) Okamura N, Shiga Y, Furumoto S, et al. In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET. Eur J Nucl Med Mol Imaging. 2010; 37: 934-41
|
|
|
60) Small GW, Kepe V, Ercoli LM, et al. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006; 355: 2652-63
|
|
|
61) Small GW, Siddarth P, Burggren AC, et al. Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without demen-tia. Arch Gen Psychiatry. 2009; 66: 81-7
|
|
|
62) Shin J, Lee SY, Kim SJ, et al. Voxel-based analysis of Alzheimerʼs disease PET imaging using a triplet of radiotracers: PIB, FDDNP, and FDG. Neuroimage. 2010; 52: 488-96
|
|
|
63) Barthel H, Gertz HJ, Dresel S, et al. Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimerʼs disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011; 10: 424-35
|
|
|
64) Clark CM, Schneider JA, Bedell BJ, et al. Use of florbetapir-PET for imaging beta-amyloid pathol-ogy. JAMA. 2011; 305: 275-83
|
|
|
65) Vandenberghe R, Van Laere K, Ivanoiu A, et al. 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol. 2010; 68: 319-29
|
|
|
66) Jureus A, Swahn BM, Sandell J, et al. Charac-terization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010; 114: 784-94
|
|
|
67) Herholz K, Ebmeier K. Clinical amyloid imaging in Alzheimerʼs disease. Lancet Neurol. 2011; 10: 667-70
|
|
|
68) Villemagne VL, Ong K, Mulligan RS, et al. Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias. J Nucl Med. 2011; 52: 1210-7
|
|
|
69) Okamura N, Yanai K. Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimerʼs disease. IDrugs. 2010; 13: 890-9
|
|
|
70) Bobinski M, Wegiel J, Wisniewski HM, et al. Neurofibrillary pathology--correlation with hippocampal formation atrophy in Alzheimer disease. Neurobiol Aging. 1996; 17: 909-19
|
|
|
71) Guillozet AL, Weintraub S, Mash DC, Mesulam MM. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol. 2003; 60: 729-36
|
|
|
72) Okamura N, Suemoto T, Furumoto S, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimerʼs disease. J Neurosci. 2005; 25: 10857-62
|
|
|
73) Fodero-Tavoletti MT, Okamura N, Furumoto S, et al. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimerʼs disease. Brain. 2011; 134(Pt 4): 1089-100
|
|
|