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2) Arumugam P, Malik P. Genetic therapy for beta-thalassemia: from the bench to the bedside. Am Soc Hematol Educ Program. 2010; 445-50
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3) Papanikolaou E, Anagnou NP. Major challenges for gene therapy of thalassemia and sickle cell disease. Curr Gene Ther. 2010; 10: 404-12
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4) 久米晃啓. 造血幹細胞遺伝子治療後のLMO2, EVI1の活性化. In: 高久史麿, 他編. Annual Review 血液 2011. 東京: 中外医学社; 2011. p.40-7
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5) Cavazzana-Calvo M, Payen E, Negre O, et al. Transfusion independence and HMGA2 activation after gene therapy of human β-thalasssaemia. Nature. 2010; 467: 318-22
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7) Imren S, Payen E, Westerman KA, et al. Permanent and panerythroid correction of murine β-thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A. 2002; 99: 14380-5
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9) Ott MG, Schmidt M, Schwarzwaelder K, et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006; 12: 401-9
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14) Fedele M, Visone R, De Martino I, et al. HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell. 2006; 9: 459-71
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15) Vallone D, Battista S, Pierantoni GM, et al. Neoplastic transformation of rat thyroid cells erquires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. EMBO J. 1997; 16: 5310-21
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16) Tessari MA, Gostissa M, Altamura S, et al. Transcriptional activation of the cyclin A gene by the architecturial transcription factor HMGA2. Mol Cell Biol. 2003; 23: 9104-6
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17) Andrieux J, Bilhou-Nabera C, Lippert E, et al. Expression of HMGA2 in PB leukocytes and purified CD34+ cells from controls and patients with myelofibrosis and myeloid dysplasia. Leuk Lymphoma. 2006; 47: 1956-9
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18) Nishino J, Kim I, Chada K, et al. Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression. Cell. 2008; 135: 227-39
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19) Fedele MS, Battista S, Kenyon L, et al. Over-expression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene. 2002; 21: 3190-8
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24) 村上良子, 木下タロウ. サラセミアの遺伝子治療が明らかにした造血幹細胞のクローン性増殖メカニズム. 医学のあゆみ. 2011; 237: 233-6
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25) Mayr C, Hemann MT, Bartel BP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science. 2007; 315: 1576-9
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26) Mayr C, Bartel DP. Widespread shortening of 3ʼUTRs by alternative cleavage and polyadenyla-tion activates oncogenes in cancer cells. Cell. 2009; 138: 673-84
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27) Inoue N, Murakami Y, Kinoshita T. Molecular genetics of paroxysmal nocturnal hemo-globinuria. Int J Hematol. 2003; 77: 107-12
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28) Inoue N, Izumi-Sarumaru T, Murakami Y, et al. Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood. 2006; 108: 4232-6
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