|
1) Staub O, Dho S, Henry P, et al. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na＋ channel deleted in Liddle, s syndrome. Embo J. 1996; 15: 2371-80
|
|
|
|
2) Meneton P, Jeunemaitre X, de Wardener HE, et al. Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev. 2005; 85: 679-715
|
|
|
|
|
3) Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001; 104: 545-56
|
|
|
|
|
|
4) O, Shaughnessy KM, Karet FE. Salt handling and hypertension. J Clin Invest. 2004; 113: 1075-81
|
|
|
|
|
|
5) Snyder PM. Minireview: regulation of epithelial Na＋ channel trafficking. Endocrinology. 2005; 146: 5079-85
|
|
|
|
|
|
6) Gormley K, Dong Y, Sagnella GA. Regulation of the epithelial sodium channel by accessory proteins. Biochem J. 2003; 371(Pt 1): 1-14
|
|
|
|
|
|
7) Snyder PM. The epithelial Na＋ channel: cell surface insertion and retrieval in Na＋ homeostasis and hypertension. Endocr Rev. 2002; 23: 258-75
|
|
|
|
|
|
8) Persaud A, Alberts P, Amsen EM, et al. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Mol Syst Biol. 2009; 5: 333
|
|
|
|
|
|
9) Kimura T, Kawabe H, Jiang C, et al. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A. 2011; 108: 3216-21
|
|
|
|
|
|
10) Oberfeld B, Ruffieux-Daidie D, Vitagliano JJ, et al. Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na＋ channel (ENaC)-ubiquitylating enzyme Nedd4-2. Am J Physiol Renal Physiol. 2011; 301: F189-96
|
|
|
|
|
|
11) Verrey F, Fakitsas P, Adam G, et al. Early transcriptional control of ENaC(de)ubiquitylation by aldosterone. Kidney Int. 2008; 73: 691-6
|
|
|
|
|
|
12) Kumar S, Tomooka Y, Noda M. Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992; 185: 1155-61
|
|
|
|
|
|
13) Ishikawa K, Nagase T, Nakajima D, et al. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1997; 4: 307-13
|
|
|
|
|
|
14) Harvey KF, Dinudom A, Cook DI, et al. The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. J Biol Chem. 2001; 276: 8597-601
|
|
|
|
|
|
15) Kamynina E, Debonneville C, Bens M, et al. A novel mouse Nedd4 protein suppresses the activity of the epithelial Na＋ channel. Faseb J. 2001; 15: 204-14
|
|
|
|
|
|
16) Kamynina E, Debonneville C, Hirt RP, et al. Liddle's syndrome: a novel mouse Nedd4 isoform regulates the activity of the epithelial Na(＋) channel. Kidney Int. 2001; 60: 466-71
|
|
|
|
|
|
17) Kamynina E, Tauxe C, Staub O. Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(＋) channel regulation. Am J Physiol Renal Physiol. 2001; 281: F469-77
|
|
|
|
|
|
18) Dunn DM, Ishigami T, Pankow J, et al. Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript. J Hum Genet. 2002; 47: 665-76
|
|
|
|
|
19) Ishigami T, Umemura M, Araki N, et al. NEDD4L protein truncating variant(v13[G/A]: rs4149601)is associated with essential hypertension in a sample of the Japanese population. Geriatrics & Gerontology International. 2007; 7: 114-7
|
|
|
|
|
|
20) Fava C, von Wowern F, Berglund G, et al. 24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes. Kidney Int. 2006; 70: 562-9
|
|
|
|
|
|
21) Svensson-Farbom P, Wahlstrand B, Almgren P, et al. A functional variant of the NEDD4L gene is associated with beneficial treatment response with beta-blockers and diuretics in hypertensive patients. J Hypertens. 2011; 29: 388-95
|
|
|
|
|
|
22) Dahlberg J, Nilsson LO, von Wowern F, et al. Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP. PLoS ONE. 2007; 2: e432
|
|
|
|
|
|
23) Araki N, Umemura M, Miyagi Y, et al. Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension. Hypertension. 2008; 51: 773-7
|
|
|
|
|
|
24) Ishigami T, Araki N, Umemura S. Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain. Hypertension. 2010; 55: e10; author reply e11
|
|
|
|
|
|
25) Diez J. Altered regulation of the epithelial sodium channel in hypertension. From genes to therapeutics. J Hypertens. 2011; 29: 204-6
|
|
|
|
|
|
26) Luo F, Wang Y, Wang X, et al. A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. Hypertension. 2009; 54: 796-801
|
|
|
|
|
|
27) Shi PP, Cao XR, Sweezer EM, et al. Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Rena Physiol. 2008; 295: F462-70
|
|
|
|
|
|
28) Pradervand S, Wang Q, Burnier M, et al. A mouse model for Liddle's syndrome. J Am Soc Nephrol. 1999; 10: 2527-33
|
|
|
|
|
|
29) Araki N, Ishigami T, Ushio H, et al. Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L. Biochem Biophys Res Commun. 2009; 388: 290-6
|
|
|
|
|
|
30) 石上友章. 本態性高血圧症の分子メカニズムの解明とトランスレーショナルリサーチ(1) アンジオテンシノーゲン遺伝子と尿細管レニン・アンジオテンシン系. 横浜医学. 2006; 57: 521-37
|
|
|
|
|
|
31) 石上友章. 本態性高血圧症の分子メカニズムの解明とトランスレーショナルリサーチ(2) アルドステロン感受性ネフロン(ASDN)における上皮性ナトリウムチャネル(ENaC)の制御因子-Nedd4Lのtranscriptome 解析と本態性高血圧症に関する検討. 横浜医学. 2007; 58: 57-72
|
|
|
|
|