1) Wilson FH, Disse-Nicodeme S, Choate KA, et al. Human hypertension caused by mutations in WNK kinases. Science. 2001; 293: 1107-12
|
|
|
2) Gordon RD, Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate. Hypertension. 1986; 8: 93-102
|
|
|
3) Yang SS, Morimoto T, Rai T, et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4 (D561A/+)knockin mouse model. Cell Metab. 2007; 5: 331-44
|
|
|
4) Xu B, English JM, Wilsbacher JL, et al. WNK1, a novel mammalian serin/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem. 2000; 275: 16795-801
|
|
|
5) Uchida S. Pathophysiological roles of WNK kinases in the kidney. Pflugers Arch. 2010; 460: 695-702
|
|
|
6) Delaloy C, Lu J, Houot AM, et al. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol. 2003; 23: 9208-21
|
|
|
7) O'Reilly M, Marshall E, Speirs HJ, et al. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol. 2003; 14: 2447-56
|
|
|
8) Hadchouel J, Soukaseum C, Büsst C, et al. Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension. Proc Natl Acad Sci U S A. 2010; 107: 18109-14
|
|
|
9) Delaloy C, et al. Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues. Hypertension. 2008; 52: 1149-54
|
|
|
10) Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 2005; 46: 295-300
|
|
|
11) Gong H, Tang Z, Yang Y, et al. A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene. Endocrine. 2008; 33: 230-4
|
|
|
12) Vitari AC, Deak M, Morrice NA, et al. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J. 2005; 391(Pt 1): 17-24
|
|
|
13) Rafiqi FH, Zuber AM, Glover M, et al. Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2010; 2: 63-75
|
|
|
14) Yang SS, Lo YF, Wu CC, et al. SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol. 2010; 21: 1868-77
|
|
|
15) Ohta A, Rai T, Yui N, et al. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009; 18: 3978-86
|
|
|
16) Chiga M, Rai T, Yang SS, et al. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int. 2008; 74: 1403-9
|
|
|
17) Vallon V, Schroth J, Lang F, et al. Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol. 2009; 297: F704-12
|
|
|
18) Xu BE, Stippec S, Chu PY, et al. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A. 2005; 102: 10315-20
|
|
|
19) Talati G, Ohta A, Rai T, et al. Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun. 2010; 393: 844-8
|
|
|
20) Naito S, Ohta A, Sohara E, et al. Regulation of WNK1 kinase by extracellular potassium. Clin Expe Nephrol. 2010 (in press)
|
|
|
21) Rozansky DJ, Cornwall T, Subramanya AR, et al. Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest. 2009; 119: 2601-12
|
|
|
22) Yang CL, Zhu X, Ellison DH. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest. 2007; 117: 3403-11
|
|
|
23) Wang Y, O'Connell JR, McArdle PF, et al. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A. 2009; 226-31
|
|
|