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2) Cousin C, Bracquart D, Contrepas A, et al. Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma. Hypertension. 2009; 53: In press
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3) Sakoda M, Ichihara A, Kaneshiro Y, et al. (Pro)renin receptor-mediated activation of mito-gen-activated protein kinases in human vascular smooth muscle cells. Hyper Res. 2007; 30: 1139-46
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4) Nabi AHMN, Kageshima A, Uddin M, et al. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor pre-pared by a baculovirus expression system. Int J Mol Med. 2006; 18: 483-8
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5) Derkx F, Schalekamp M. Human prorenin: patho-physiology and clinical implications. Clin Exp Hypertens. 1988; A10: 1213-25
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6) Nabi AHMN, Uddin M, Nakagawa T, et al. Role of “handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci. 2007; 12: 4810-7
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7) Huang Y, Noble N, Zhang J, et al. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int. 2007; 72: 42-52
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9) Saris J, ‘tHoen P, Garrelds I, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension. 2006; 48: 564-71
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10) Feldt S, Batenburg WW, Mazak I, et al. Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension. 2008; 51: 682-8
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11) Nabi AHMN, Biswas KB, Nakagawa T, et al. ‘Decoy peptide' region (RIFLKRMPSI) of prorenin prosegment plays a crucial role in prorenin binding to the (pro)renin receptor. Int J Mol Med. 2009; 24: 83-9
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12) Ichihara A, Hayashi M, Kaneshiro Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle" region for non-proteolytic activation of prorenin. J Clin Invest. 2004; 114: 1128-35
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13) Takahashi H, Ichihara A, Kaneshiro Y, et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol. 2007; 18: 2054-61
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14) Ichihara A, Sakoda M, Mito-Kurauchi A, et al. Involvement of receptor-bound prorenin in development of nephropathy in db/db mice. J Am Soc Hypertens. 2008; 2: 332-40
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15) Satofuka S, Ichihara A, Nagai N, et al. (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation. Diabetes. 2009; 58: 1625-33
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16) Ichihara A, Kaneshiro Y, Takemitsu T, et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006; 47: 894-900
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17) Ichihara A, Kaneshiro Y, Takemitsu T, et al. Contribution of non-proteolytically activated pro-renin in glomeruli to hypertensive renal damage. J Am Soc Nephrol. 2006; 17: 2495-503
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18) Susic D, Zhou X, Frohlich ED, et al. Cardio-vascular effects of prorenin blockade in genetically hypertensive rats (SHR) on normal and high salt diet. Am J Physiol Heart Circ Physiol. 2008; 295: H1117-21
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19) Satofuka S, Ichihara A, Nagai N, et al. (Pro)renin receptor promotes choroidal nepvascularization by activating its signal transduction and tissue renin-angiotensin system. Am J Pathol. 2008; 173: 1911-8
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20) Kaneshiro Y, Ichihara A, Sakoda M, et al. Slowly progressive, angiotensin II-independent glomerulo-sclerosis in human-renin/prorenin-receptor-transgenic rats. J Am Soc Nephrol. 2007; 18: 1789-95
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21) Feldt S, Maschke U, Dechend R, et al. The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol. 2008; 19: 743-8
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22) Muller DN, Klanke B, Feldt S, et al. (Pro)renin receptor peptide inhibitor “handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 2008; 51: 676-81
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24) Advani A, Kelly DJ, Cox AJ, et al. The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney. Hypertension. 2009; 54: 261-9
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25) Louagie E, Taylor NA, Flamez D, et al. Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. Proc Natl Acad Sci U S A. 2008; 105: 12319-24
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