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2) Jaye M, Lynch KJ, Krawiec J, et al. A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet. 1999; 21: 424-8
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3) McCoy MG, Sun GS, Marchadier D, et al. Characterization of the lipolytic activity of endo-thelial lipase. J Lipid Res. 2002; 43: 921-9
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4) Griffon N, Jin W, Petty TJ, et al. Identification of the active form of endothelial lipase: a homo-dimer in a head-to-tail conformation. J Biol Chem. 2009; 284: 23322-30
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5) Jin W, Wang X, Millar JS, et al. Hepatic proprotein convertases modulate HDL metabo-lism. Cell Metab. 2007; 6: 129-36
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6) Shimamura M, Matsuda M, Yasumo H, et al. Angiopoietin-like protein 3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol. 2007; 27: 366-72
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7) Caiazza D, Jahangiri A, Rader DJ, et al. Apolipoproteins regulate the kinetics of endo-thelial lipase-mediated hydrolysis of phospho-lipids in reconstituted high-density lipoproteins. Biochemistry. 2004; 43: 11898-905
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8) Jahangiri A, Rader DJ, Marchadier D, et al. Evidence that endothelial lipase remodels high density lipoproteins without mediating the disso-ciation of apolipoprotein A-I. J Lipid Res. 2005; 46: 896-903
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9) Gauster M, Oskolkova OV, Innerlohinger J, et al. Endothelial lipase-modified high-density lipo-protein exhibits diminished ability to mediate SR-BI (scavenger receptor B type I)-dependent free-cholesterol efflux. Biochem J. 2004; 382(Pt 1): 75-82
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10) Ishida T, Choi S, Kundu RK, et al. Endothelial lipase is a major determinant of HDL level. J Clin Invest. 2003; 111: 347-55
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11) Ma K, Cilingiroglu M, Otvos JD, et al. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003; 100: 2748-53
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12) Fuki IV, Blanchard N, Jin W, et al. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated path-way. J Biol Chem. 2003; 278: 34331-8
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13) Strauss JG, Zimmermann R, Hrzenjak A, et al. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-asso-ciated cholesterol esters independent of its enzymic activity. Biochem J. 2002; 368(Pt 1): 69-79
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14) Kojma Y, Hirata K, Ishida T, et al. Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation. J Biol Chem. 2004; 279: 54032-8
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15) Broedl UC, Maugeais C, Marchadier D, et al. Effects of nonlipolytic ligand function of endothelial lipase on high density lipoprotein metabolism in vivo. J Biol Chem. 2003; 278: 40688-93
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16) Azumi H, Hirata K, Ishida T, et al. Immuno-histochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res. 2003; 58: 647-54
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17) Hirata K, Ishida T, Matsushita H, et al. Regulated expression of endothelial cell-derived lipase. Biochem Biophys Res Commun. 2000; 272: 90-3
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18) Shiu SW, Tan KC, Huang Y, et al. Type 2 diabetes mellitus and endothelial lipase. Atherosclerosis. 2008; 198: 441-7
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19) Shimokawa Y, Hirata K, Ishida T, et al. Increased expression of endothelial lipase in rat models of hypertension. Cardiovasc Res. 2005; 66: 594-600
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20) Wang X, Jin W, Rader DJ. Upregulation of macrophage endothelial lipase by toll-like recep-tors 4 and 3 modulates macrophage interleukin-10 and -12 production. Circ Res. 2007; 100: 1008-15
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21) Ishida T, Choi SY, Kundu RK, et al. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem. 2004; 279: 45085-92
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22) deLemos AS, Wolfe ML, Long CJ, et al. Iden-tification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation. 2002; 106: 1321-6
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23) Paradis ME, Couture P, Bosse Y, et al. The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women. J Lipid Res. 2003; 44: 1902-8
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24) Brown RJ, Edmondson AC, Griffon N, et al. A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis. J Lipid Res. 2009 May 3. [Epub ahead of print]
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25) Yamakawa-Kobayashi K, Yanagi H, Endo K, et al. Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children. Hum Genet. 2003; 113: 311-5
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26) Shimizu M, Kanazawa K, Hirata K, et al. Endothelial lipase gene polymorphism is asso-ciated with acute myocardial infarction, independ-ently of high-density lipoprotein-cholesterol levels. Circ J. 2007; 71: 842-6
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27) Tang NP, Wang LS, Yang L, et al. Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population. J Lipid Res. 2008; 49: 369-75
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28) Badellino KO, Wolfe ML, Reilly MP, et al. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coro-nary atherosclerosis. PLoS Med. 2006; 3: e22
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29) Badellino KO, Wolfe ML, Reilly MP, et al. Endothelial lipase is increased in vivo by in-flammation in humans. Circulation. 2008; 117: 678-85
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30) Paradis ME, Badellino KO, Rader DJ, et al. Endothelial lipase is associated with inflammation in humans. J Lipid Res. 2006; 47: 2808-13
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31) Fujii H, Fukuda A, Tanaka M, et al. Putative role of endothelial lipase in dialysis patients with hypoalbuminemia and inflammation. Am J Nephrol. 2008; 28: 974-81
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32) Qiu G, Hill JS. Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. J Lipid Res. 2007; 48: 2112-22
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33) Miida T, Seino U, Miyazaki O, et al. Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conver-sion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling. Atherosclerosis. 2008; 200: 329-35
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34) Goodman KB, Bury MJ, Cheung M, et al. Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett. 2009; 19: 27-30
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35) Ko KW, Paul A, Ma K, et al. Endothelial lipase modulates HDL but has no effect on athero-sclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res. 2005; 46: 2586-94
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36) Ahmed W, Orasanu G, Nehra V, et al. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mecha-nism for high-density lipoprotein-mediated repres-sion of leukocyte adhesion. Circ Res. 2006; 98: 490-8
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