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1) Nakae J, Biggs WH, Kitamura T, et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002; 32: 245-53
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2) Nakae J, Kitamura T, Kitamura Y, et al. The forkhead transcription factor foxo1 regulates adipocyte differentiation. Dev Cell. 2003; 4: 119-29
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3) Nakae J, Cao Y, Oki M, et al. Forkhead trans-cription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes. 2008; 57: 563-76
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4) Matsumoto M, Han S, Kitamura T, et al. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest. 2006; 116: 2464-72
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5) Matsumoto M, Pocai A, Rossetti L, et al. Im-paired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007; 6: 208-16
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6) Kitamura T, Nakae J, Kitamura Y, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002; 110: 1839-47
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7) Kitamura YI, Kitamura T, Kruse JP, et al. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2005; 2: 153-63
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8) Kitamura T, Feng Y, Kitamura YI, et al. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006; 12: 534-40
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9) Kitamura T, Kitamura YI, Funahashi Y, et al. A Foxo/Notch pathway controls myogenic differ-entiation and fiber type specification. J Clin Invest. 2007; 117: 2477-85
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10) Kitamura T, Kitamura YI, Kobayashi M, et al. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol Cell Biol. 2009; 29: 4417-30
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11) Zhang W, Patil S, Chauhan B, et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem. 2006; 281: 10105-17
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12) Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003; 423: 550-5
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13) Daitoku H, Yamagata K, Matsuzaki H, et al. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes. 2003; 52: 642-9
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14) Kamei Y, Miura S, Suganami T, et al. Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor. Endocrinology. 2008; 149: 2293-305
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15) Biddinger SB, Hernandez-Ono A, Rask-Madsen C, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008; 7: 125-34
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16) Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 2008; 7: 95-6
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17) Dentin R, Hedrick S, Xie J, et al. Hepatic glucose sensing via the CREB coactivator CRTC2. Science. 2008; 319: 1402-5
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18) Issad T, Kuo M. O-GlcNAc modification of transcription factors, glucose sensing and gluco-toxicity. Trends Endocrinol Metab. 2008; 19: 380-9
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19) Yamagata K, Daitoku H, Takahashi Y, et al. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell. 2008; 32: 221-31
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20) Housley MP, Rodgers JT, Udeshi ND, et al. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008; 283: 16283-92
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21) Kim MS, Pak YK, Jang PG, et al. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci. 2006; 9: 901-6
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22) Belgardt BF, Husch A, Rother E, et al. PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress re-sponse. Cell Metab. 2008; 7: 291-301
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23) Fukuda M, Jones JE, Olson D, et al. Monitoring FoxO1 localization in chemically identified neurons. J Neurosci. 2008; 28: 13640-8
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24) Abid MR, Nadeau RJ, Spokes KC, et al. Hepatocyte growth factor inhibits VEGF-fork-head-dependent gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2008; 28: 2042-8
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