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1) Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. 2005; 24: 7410-25
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2) Salih DA, Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol. 2008; 20: 126-36
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3) Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999; 96: 857-68
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4) Kops GJ, de Ruiter ND, De Vries-Smits AM, et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature. 1999; 398: 630-4
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5) Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wort-mannin-sensitive pathway. J Biol Chem. 1999; 274: 15982-5
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6) Rena G, Guo S, Cichy SC, et al. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem. 1999; 274: 17179-83
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7) Tang ED, Nunez G, Barr FG, et al. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem. 1999; 274: 16741-6
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8) Biggs WH, 3rd Meisenhelder J, Hunter T, et al. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A. 1999; 96: 7421-6
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9) Brunet A, Park J, Tran H, et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol. 2001; 21: 952-65
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10) Brunet A, Kanai F, Stehn J, et al. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002; 156: 817-28
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11) Cahill CM, Tzivion G, Nasrin N, et al. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem. 2001; 276: 13402-10
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12) Rena G, Prescott AR, Guo S, et al. Roles of the forkhead in rhabdomyosarcoma (FKHR) phos-phorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem J. 2001; 354: 605-12
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13) Brownawell AM, Kops GJ, Macara IG, et al. Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Mol Cell Biol. 2001; 21: 3534-46
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14) Jacobs FM, van der Heide LP, Wijchers PJ, et al. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem. 2003; 278: 35959-67
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15) Lin K, Hsin H, Libina N, et al. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet. 2001; 28: 139-45
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16) Nakae J, Kitamura T, Silver DL, et al. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest. 2001; 108: 1359-67
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17) Nakae J, Biggs WH, Kitamura T, et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002; 32: 245-53
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18) Matsumoto M, Pocai A, Rossetti L, et al. Impaired regulation of hepatic glucose produc-tion in mice lacking the forkhead transcription factor foxo1 in liver. Cell Metab. 2007; 6: 208-16
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19) Dong XC, Copps KD, Guo S, et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008; 8: 65-76
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20) Puig O, Marr MT, Ruhf ML, et al. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 2003; 17: 2006-20
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21) Ide T, Shimano H, Yahagi N, et al. SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol. 2004; 6: 351-7
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22) Du K, Herzig S, Kulkarni RN, et al. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003; 300: 1574-7
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23) Matsumoto M, Han S, Kitamura T, et al. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest. 2006; 116: 2464-72
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24) Luong N, Davies CR, Wessells RJ, et al. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab. 2006; 4: 133-42
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25) Teleman AA, Chen YW, Cohen SM. Drosophila melted modulates FOXO and TOR activity. Dev Cell. 2005; 9: 271-81
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