文献リスト

1) Cardell BS. Pathological findings in deaths from asthma. Int Arch Allergy Appl Immunol. 1956; 9: 189-99

2) Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol. 1960; 13: 27-33

3) Aikawa T, Shimura S, Sasaki H, et al. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest. 1992; 101: 916-21

4) Jany B, Basbaum CB. Mucin in disease. Modification of mucin gene expression in airway disease. Am Rev Respir Dis. 1991; 144: S38-41

5) Zuhdi Alimam M, Piazza FM, Selby DM, et al. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol. 2000; 22: 253-60

6) Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science. 1998; 282: 2258-61

7) Amishima M, Munakata M, Nasuhara Y, et al. Expression of epidermal growth factor and epidermal growth factor receptor immuno-reactivity in the asthmatic human airway. Am J Respir Crit Care Med. 1998; 157: 1907-12

8) Takeyama K, Dabbagh K, Lee HM, et al. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999; 96: 3081-6

9) Nakanishi A, Morita S, Iwashita H, et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci U S A. 2001; 98: 5175-80

10) Tesfaigzi Y, Fischer MJ, Martin AJ, et al. Bcl-2 in LPS- and allergen-induced hyperplastic mucous cells in airway epithelia of Brown Norway rats. Am J Physiol Lung Cell Mol Physiol. 2000; 279: L1210-7

11) Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev. 2006; 86: 245-78

12) Evans CM, Kim K, Tuvim MJ, et al. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med. 2009; 15: 4-11

13) Pigny P, Guyonnet-Duperat V, Hill AS, et al. Human mucin genes assigned to 11p15. 5: identification and organization of a cluster of genes. Genomics. 1996; 38: 340-52

14) Ordonez CL, Khashayar R, Wong HH, et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med. 2001; 163: 517-23

15) Henderson WR Jr, Lewis DB, Albert RK, et al. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J Exp Med. 1996; 184: 1483-94

16) Temann UA, Prasad B, Gallup MW, et al. A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hyper-secretion. Am J Respir Cell Mol Biol. 1997; 16: 471-8

17) Humbles AA, Lloyd CM, McMillan SJ, et al. A critical role for eosinophils in allergic airways remodeling. Science. 2004; 305: 1776-9

18) Lee JJ, Dimina D, Macias MP, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science. 2004; 305: 1773-6

19) Cohn L, Homer RJ, Marinov A, et al. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med. 1997; 186: 1737-47

20) Temann UA, Ray P, Flavell RA. Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J Clin Invest. 2002; 109: 29-39

21) Kuperman DA, Huang X, Nguyenvu L, et al. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol. 2005; 175: 3746-52

22) Kuperman DA, Huang X, Koth LL, et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduc-tion in asthma. Nat Med. 2002; 8: 885-9

23) Tanabe T, Fujimoto K, Yasuo M, et al. Modulation of mucus production by inter-leukin-13 receptor alpha 2 in the human airway epithelium. Clin Exp Allergy. 2008; 38: 122-34

24) Young HW, Williams OW, Chandra D, et al. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5'elements. Am J Respir Cell Mol Biol. 2007; 37: 273-90

25) Fujisawa T, Ide K, Holtzman MJ, et al. Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells. Respirology. 2008; 13: 191-202

26) Lee PJ, Zhang X, Shan P, et al. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006; 116: 163-73

27) Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med. 2001; 163: 511-6

28) Kohri K, Ueki IF, Nadel JA. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung Cell Mol Physiol. 2002; 283: L531-40

29) Park JA, Tschumperlin DJ. Chronic intermittent mechanical stress increases MUC5AC protein expression. Am J Respir Cell Mol Biol. 2009 Epub ahead of print

30) Wang SW, Oh CK, Cho SH, et al. Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts. J Allergy Clin Immunol. 2005; 115: 287-94

31) Okumura S, Sagara H, Fukuda T, et al. Fc epsilon RI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells. J Allergy Clin Immunol. 2005; 115: 272-9

32) Pantano C, Ather JL, Alcorn JF, et al. Nuclear factor-kappa B activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med. 2008; 177: 959-69

33) Shim JJ, Dabbagh K, Ueki IF, et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol. 2001; 280: L134-40

34) Tyner JW, Kim EY, Ide K, et al. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest. 2006; 116: 309-21

35) Kondo M, Tamaoki J, Takeyama K, et al. Elimination of IL-13 reverses established goblet cell metaplasia into ciliated epithelia in airway epithelial cell culture. Allergol Int. 2006; 55: 329-36

36) Wan H, Kaestner KH, Ang SL, et al. Foxa2 regulates alveolarization and goblet cell hyper-plasia. Development. 2004; 131: 953-64

37) Zhen G, Park SW, Nguyenvu LT, et al. IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production. Am J Respir Cell Mol Biol. 2007; 36: 244-53

38) Patel AC, Brett TJ, Holtzman MJ. The role of CLCA proteins in inflammatory airway disease. Annu Rev Physiol. 2009; 71: 425-49

39) Nakano T, Inoue H, Fukuyama S, et al. Niflumic acid suppresses interleukin-13 -induced asthma phenotypes. Am J Respir Crit Care Med. 2006; 173: 1216-21

40) Hegab AE, Sakamoto T, Nomura A, et al. Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1. Chest. 2007; 131: 1149-56

41) Robichaud A, Tuck SA, Kargman S, et al. Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma. Am J Respir Cell Mol Biol. 2005; 33: 303-14

42) Park KS, Korfhagen TR, Bruno MD, et al. SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest. 2007; 117: 978-88

43) Xiang YY, Wang S, Liu M, et al. A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nat Med. 2007; 13: 862-7

44) Zhu L, Lee PK, Lee WM, et al. Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway. Am J Respir Cell Mol Biol. 2009; 40: 610-9

45) Tadaki H, Arakawa H, Mizuno T, et al. Double-stranded RNA and TGF-alpha promote MUC5AC induction in respiratory cells. J Immunol. 2009; 182: 293-300

46) Schwalm K, Stevens JF, Jiang Z, et al. Expression of the proapoptotic protein Bax is reduced in bronchial mucous cells of asthmatic subjects. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L1102-9

47) Takeyama K, Tamaoki J, Kondo M, et al. Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen. Clin Exp Allergy. 2008; 38: 857-65

NPO医学中央雑誌刊行会 https://www.jamas.or.jp/ info@jamas.or.jp