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1) Gordon RD, et al. Hypertension and severe hyperkalemia associated with suppression of rennin and aldosterone and completely reversed by dietary sodium restriction. Australias Ann Med. 1970; 4: 287-94
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2) Wilson FH, et al. Human hypertension caused by mutations in WNK kinase. Science. 2001; 293: 1107-12
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3) Chiga M, et al. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int. 2008; 74: 1403-9
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4) Xu B, et al. WNK1, a novel mammmarian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem. 2000; 275: 16795-801
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5) Verissimo F, et al. WNK kinase, a novel protein kinase subfamily in multi-cellular organisms. Oncogene. 2001; 20: 5562-9
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6) O'Reilly M, et al. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol. 2003; 14: 2447-56
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7) Verissimo F, et al. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Oncogene. 2007; 26: 6071-81
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8) Simon H, et al. Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). Gene. 2005; 35: 109-19
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9) Rinehart J, et al. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A. 2005; 102: 16777-82
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10) Kahle KT, et al. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci U S A. 2005; 102: 16783-8
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11) Kahle KT, et al. WNK4 regulates apical and basolateral Cl-flux in extrarenal epithelia. Proc Natl Acad Sci U S A. 2004; 101: 2064-9
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12) Wilson FH, et al. Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A. 2003; 100: 680-4
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13) Yang CL, et al. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003; 111: 1039-45
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14) Kahle KT, et al. WNK4 regulates the balance between renal NaCl reabsorption and K+ sectetion. Nature Genet. 2003; 35: 372-6
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15) Yang SS, et al. Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells. Biochem. Biophys Res Commun. 2004; 330: 410-4
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16) Yang SS, et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a WNKD561/+ knock-in mouse model. Cell metabolism. 2007; 5: 331-44
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17) Piechotta K, et al. Cation chloride cotransporter interact with the stress-related kinase Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response1 (OSR1). J Biol Chem. 2002; 277: 50812-9
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18) Dowd BF, et al. PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of Na-K-Cl cotransporter (NKCC1). J Biol Chem. 2003; 278: 27347-53
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19) Moriguchi T, et al. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporter via the STE20-related kinases, SPAK and OSR1. J Biol Chem. 2005; 280: 42685-963
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20) Ohta A, et al. Targeted disruption of the wnk4 gene decreases phosphorylation of the Na-Cl cotransporter, increases Na excretion, and lowers blood pressure. Hum Mol Genet. (Epub ahead of print)
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21) Schultheis PJ, et al. Phenotype resembling Gitelman's syndrome in mice lacking the apical Na-Cl cotransporter of the distal convoluted tubule. J Biol Chem. 1998; 273: 29150-5
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22) Wang Y, et al. Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A. 2008; 106: 226- 31
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23) Zambrowicz BP, et al. Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003; 100: 14109-14
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