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2) Coyne KS, Sexton CC, Irwin DE, et al. The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU Int. 2008; 101: 1388-95
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15) Geirsson G, Fall M, Lindstr MS. The ice-water test- a simple and valuable supplement to routine cystometry. Br J Urol. 1993; 71: 681-5
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18) Apostolidis A, Popat R, Yiangou Y, et al. Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol. 2005; 174: 977-82
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19) Brady CM, Apostolidis AN, Harper M, et al. Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9. 5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatment. BJU Int. 2004; 93: 770-6
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20) Silva C, Ribeiro MJ, Cruz F. The effect of intravesical resiniferatoxin in patients with idiopathic detrusor instability suggests that involuntary detrusor contractions are triggered by C-fiber input. J Urol. 2002; 168: 575-9
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21) Yokoyama T, Nozaki K, Fujita O, et al. Role of C afferent fibers and monitoring of intravesical resiniferatoxin therapy for patients with idiopathic detrusor overactivity. J Urol. 2004; 172: 596-600
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22) Yoshimura N, Seki S, Chancellor MB, et al. Targeting afferent hyperexcitability for therapy of the painful bladder syndrome. Urology. 2002; 59 (Suppl 5A): 61-7
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23) Johansson SL, Ogawa K, Fall M. The pathology of interstitial cystitis. In: Sant GR, editor. Interstitial Cystitis. Philadelphia: Lippincott-Raven; 1997. p. 143-51
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26) Cockayne DA, Hamilton SG, Zhu QM, et al. Ford APDW. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X(3)-deficient mice. Nature. 2000; 407: 1011-5
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33) Yoshida M, Inadome A, Masunaga K, et al. Effects of age and stretch on ATP release from isolated human bladder. J Urol. 2004; 171: 136A
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34) Kim Y, Yoshimura N, Masuda H, et al. Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways. Urology. 2005; 65: 238-42
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35) Dang K, Bielefeldt K, Gebhart GF. Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin. J Neurosci. 2005; 25: 3973-84
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36) de Groat WC, Yoshimura N. Pharmacology of the lower urinary tract. Ann Rev Pharmacol Toxicol. 2001; 41: 691-721
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37) Sun Y, Chai TC. Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol. 2004; 171: 448-52
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42) Cox PJ. Cyclophosphamide cystitis-identification of acrolein as the causative agent. Biochem Pharmacol. 1979; 28: 2045-9
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43) Kirimoto T, Nakano K, Irimura K, et al. Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. BJU Int. 2007; 100: 935-9
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52) Vizzard MA. Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol. 2000; 161: 273
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53) Okragly AJ, Niles AL, Saban R, et al. Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients. J Urol. 1999; 161: 438-41
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55) Vizzard MA. Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol. 2000; 161: 273
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58) Yoshimura N, Bennett NE, Hayashi Y, et al. Bladder overactivity and hyperexcitability of bladder afferent neurons following intrathecal delivery of nerve growth factor in rats. J Neurosci. 2006; 26: 10847-55
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