|
1) Funahashi T, Matsuzawa Y. Metabolic syndrome: clinical concept and molecular basis. Ann Med. 2007; 39: 482-94
|
|
|
|
2) Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006; 116: 1784-92
|
|
|
|
|
|
3) Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006; 444: 860-7
|
|
|
|
|
|
4) Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112: 1796-808
|
|
|
|
|
|
5) Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003; 112: 1821-30
|
|
|
|
|
|
6) Suganami T, Nishida J, Ogawa Y. A Paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factorα. Arterioscler Thromb Vasc Biol. 2005; 25: 2062-8
|
|
|
|
|
|
7) Nishimura S, Manabe I, Nagasaki M, et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes. 2007; 56: 1517-26
|
|
|
|
|
|
8) Nishimura S, Manabe I, Nagasaki M, et al. In vivo imaging revealed local cell dynamics in obese adipose tissue inflammation. J Clin Invest. 2008; 118: 710-21
|
|
|
|
|
|
9) Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia. 2002; 45: 1201-10
|
|
|
|
|
|
10) Summers LKM, Samra JS, Frayn KN. Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk？ Atherosclerosis. 1999; 147: 11-5
|
|
|
|
|
|
11) Summers LK. Adipose tissue metabolism, diabetes and vascular disease--lessons from in vivo studies. Diab Vasc Dis Res. 2006; 3: 12-21
|
|
|
|
|
|
12) Kim J-a, Montagnani M, Koh KK, et al. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006; 113: 1888-904
|
|
|
|
|
|
13) Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006; 116: 1793-801
|
|
|
|
|
|
14) Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005; 46: 2347-55
|
|
|
|
|
|
15) Hosogai N, Fukuhara A, Oshima K, et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007; 56: 901-11
|
|
|
|
|
|
16) Shindo T, Manabe I, Fukushima Y, et al. Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002; 8: 856-63
|
|
|
|
|
|
17) Oishi Y, Manabe I, Tobe K, et al. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 2005; 1: 27-39
|
|
|
|
|
|
18) Oishi Y, Manabe I, Tobe K, et al. SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-[delta]. Nat Med. 2008; 14: 656-66
|
|
|
|
|
|
19) Fleischman A, Shoelson SE, Bernier R, et al. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 2008; 31: 289-94
|
|
|
|
|
|
20) Larsen CM, Faulenbach M, Vaag A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med. 2007; 356: 1517-26
|
|
|
|
|