1) Okada T, Liew CW, Hu J, et al. Insulin receptors inβ-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 2007; 104: 8977-82
|
|
|
2) Hashimoto N, Kido Y, Uchida T, et al. Ablation of PDK1 in pancreaticβ cells induces diabetes as a result of loss of β cell mass. Nat Genet. 2006; 38: 589-93
|
|
|
3) Fatrai S, Elghazi L, Balcazar N, et al. Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes. 2006; 55: 318-25
|
|
|
4) Gupta RK, Gao N, Gorski RK, et al. Expansion of adultβ-cell mass in response to increased metabolic demand is dependent on HNF-4α. Gene Dev. 2007; 21: 756-69
|
|
|
5) Terauchi Y, Takamoto I, Kubota N, et al. Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest. 2007; 117: 246-57
|
|
|
6) Gunton JE, Kulkarni RN, Yim S. Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005; 122: 337-49
|
|
|
7) Heit JJ, Apelqvist AA, Gu X, et al. Calcineurin/NFAT signaling regulates pancreaticβ-cell growth and function. Nature. 2006; 443: 345-9
|
|
|
8) Teta M, Long SY, Wartschow LM, et al. Very slow turnover of β-cells in aged adult mice. Diabetes. 2005; 54: 2557-67
|
|
|
9) Maedler K, Schumann DM, Schulthess F, et al. Aging correlates with decreasedβ-cell proliferative capacity and enhanced sensitivity to apoptosis: A potential role for Fas and pancreatic duodenal homeobox-1. Diabetes. 2006; 55: 2455-62
|
|
|
10) Meier JJ, Butler AE, Galasso R, et al. Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. Diabetologia. 2006; 49: 2689-96
|
|
|
11) Yatoh S, Dodge R, Akashi T, et al. Differentiation of affinity-purified human pancreatic duct cells to β-cells. Diabetes. 2007; 56: 1802-9
|
|
|