|
1）Cordier AC, Haumont SM. Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice. Am J Anat. 1980; 157: 227-63
|
|
|
|
2）Gordon J, Wilson VA, Blair NF, et al. Functional evidence for a single endodermal origin for the thymic epithelium. Nat Immunol. 2004; 5: 546-53
|
|
|
|
|
|
3）Le Douarin NM, Jotereau FV. Tracing of cells of the avian thymus through embryonic life in interspecific chimeras. J Exp Med. 1975; 142: 17-40
|
|
|
|
|
|
4）Itoi M, Kawamoto H, Katsura Y, et al. Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage. Int Immunol. 2001; 13: 1203-11
|
|
|
|
|
|
5）Nehls M, Kyewski B, Messerle M, et al. Two genetically separable steps in the differentiation of thymic epithelium. Science. 1996; 272: 886-9
|
|
|
|
|
|
6）Blackburn CC, Manley NR. Developing a new paradigm for thymus organogenesis. Nat Rev Immunol. 2004; 4: 278-89
|
|
|
|
|
|
7）Hollander G, Gill J, Zuklys S, et al. Cellular and molecular events during early thymus development. Immunol Rev. 2006; 209: 28-46
|
|
|
|
|
|
8）Jerome LA, Papaioannou VE. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet. 2001; 27: 286-91
|
|
|
|
|
|
9）Balciunaite G, Keller MP, Balciunaite E, et al. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol. 2002; 3: 1102-8
|
|
|
|
|
|
10）Terszowski G, Muller SM, Bleul CC, et al. Evidence for a functional second thymus in mice. Science. 2006; 312: 284-7
|
|
|
|
|
|
11）Dooley J, Erickson M, Gillard GO, et al. Cervical thymus in the mouse. J Immunol. 2006; 176: 6484-90
|
|
|
|
|
|
12）Revest JM, Suniara RK, Kerr K, et al. Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J Immunol. 2001; 167: 1954-61
|
|
|
|
|
|
13）Alpdogan O, Hubbard VM, Smith OM, et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood. 2006; 107: 2453-60
|
|
|
|
|
|
14）Jiang X, Rowitch DH, Soriano P, et al. Fate of the mammalian cardiac neural crest. Development. 2000; 127: 1607-16
|
|
|
|
|
|
15）Petrie HT. Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production. Immunol Rev. 2002; 189: 8-19
|
|
|
|
|
|
16）Liu C, Saito F, Liu Z, et al. Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood. 2006; 108: 2531-9
|
|
|
|
|
|
17）Kawamoto H, Ikawa T, Ohmura K, et al. T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver. Immunity. 2000; 12: 441-50
|
|
|
|
|
|
18）Ikawa T, Masuda K, Lu M, et al. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood. 2004; 103: 530-7
|
|
|
|
|
|
19）Masuda K, Itoi M, Amagai T, et al. Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineages. J Immunol. 2005; 174: 2525-32
|
|
|
|
|
|
20）Masuda K, Kubagawa H, Ikawa T, et al. Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. Embo J. 2005; 24: 4052-60
|
|
|
|
|
|
21）Klug DB, Carter C, Gimenez-Conti IB, et al. Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol. 2002; 169: 2842-5
|
|
|
|
|
|
22）Jenkinson WE, Rossi SW, Jenkinson EJ, et al. Development of functional thymic epithelial cells occurs independently of lymphostromal interactions. Mech Dev. 2005; 122: 1294-9
|
|
|
|
|
|
23）van Ewijk W, Kawamoto H, Germeraad WT, et al. Developing thymocytes organize thymic microenvironments. Curr Top Microbiol Immunol. 2000; 251: 125-32
|
|
|
|
|
|
24）Gill J, Malin M, Hollander GA, et al. Generation of a complete thymic microenvironment by MTS24(＋) thymic epithelial cells. Nat Immunol. 2002; 3: 635-42
|
|
|
|
|
|
25）Bennett AR, Farley A, Blair NF, et al. Identification and characterization of thymic epithelial progenitor cells. Immunity. 2002; 16: 803-14
|
|
|
|
|
|
26）Rossi SW, Jenkinson WE, Anderson G, et al. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature. 2006; 441: 988-91
|
|
|
|
|
|
27）Bleul CC, Corbeaux T, Reuter A, et al. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature. 2006; 441: 992-6
|
|
|
|
|
|
28）Rodewald HR, Paul S, Haller C, et al. Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature. 2001; 414: 763-8
|
|
|
|
|
|
29）Kyewski B, Klein L. A central role for central tolerance. Annu Rev Immunol. 2006; 24: 571-606
|
|
|
|
|
|
30）Hamazaki Y, Fujita H, Kobayashi T, et al. Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol. 2007; 8: 304-11
|
|
|
|
|
|
31）Gray DH, Seach N, Ueno T, et al. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood. 2006; 108: 3777-85
|
|
|
|
|
|
32）Gillard GO, Farr AG. Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J Immunol. 2006; 176: 5815-24
|
|
|
|
|
|
33）Hollander GA, Wang B, Nichogiannopoulou A, et al. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature. 1995; 373: 350-3
|
|
|
|
|
|
34）Philpott KL, Viney JL, Kay G, et al. Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science. 1992; 256: 1448-52
|
|
|
|
|
|
35）van Ewijk W, Shores EW, Singer A. Crosstalk in the mouse thymus. Immunol Today. 1994; 15: 214-7
|
|
|
|
|
|
36）Sutherland JS, Goldberg GL, Hammett MV, et al. Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol. 2005; 175: 2741-53
|
|
|
|
|
|
37）Min D, Panoskaltsis-Mortari A, Kuro OM, et al. Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood. 2007; 109: 2529-37
|
|
|
|
|
|
38）Senoo M, Pinto F, Crum CP, et al. p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell. 2007; 129: 523-36
|
|
|
|
|
|
39）Parkman R, Weinberg KI. Immunological reconstitution following bone marrow transplantation. Immunol Rev. 1997; 157: 73-8
|
|
|
|
|
|
40）Roux E, Dumont-Girard F, Starobinski M, et al. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood. 2000; 96: 2299-303
|
|
|
|
|
|
41）Fukushi N, Arase H, Wang B, et al. Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance. Proc Natl Acad Sci USA. 1990; 87: 6301-5
|
|
|
|
|
|
42）Rossi S, Blazar BR, Farrell CL, et al. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood. 2002; 100: 682-91
|
|
|
|
|
|
43）Germeraad WT, Kawamoto H, Itoi M, et al. Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors. J Histochem Cytochem. 2003; 51: 1225-35
|
|
|
|
|