1) O'Byrne PM. Cytokines or their antagonists for the treatment of asthma. Chest. 2006; 130: 244-50
|
|
|
2) Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol. 2002; 2: 410-6
|
|
|
3) Greenhalgh CJ, Miller ME, Hilton DJ, et al. Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease. Gastroenterology. 2002; 123: 2064-81
|
|
|
4) Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol. 2000; 18: 143-64
|
|
|
5) Zhang J, Somani AK, Siminovitch KA. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin Immunol. 2000; 12: 361-78
|
|
|
6) Shuai K, Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol. 2005; 5: 593-605
|
|
|
7) Keyse SM. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol. 2000; 12: 186-92
|
|
|
8) Bundschu K, Walter U, Schuh K. The VASP-Spred-Sprouty domain puzzle. J Biol Chem. 2006; 281: 36477-81
|
|
|
9) Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 1999; 17: 255-81
|
|
|
10) Sakaguchi S, Ono M, Setoguchi R, et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 2006; 212: 8-27
|
|
|
11) Barrat FJ, Cua DJ, Boonstra A, et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med. 2002; 195: 603-16
|
|
|
12) Vieira PL, Christensen JR, Minaee S, et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol. 2004; 172: 5986-93
|
|
|
13) Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev. 2001; 182: 207-14
|
|
|
14) Yamazaki S, Inaba K, Tarbell KV, et al. Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity. Immunol Rev. 2006; 212: 314-29
|
|
|
15) Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003; 198: 1875-86
|
|
|
16) Jiang H, Chess L. Regulation of immune responses by T cells. N Engl J Med. 2006; 354: 1166-76
|
|
|
17) Tato CM, O'Shea JJ. Immunology: what does it mean to be just 17? Nature. 2006; 441: 166-8
|
|
|
18) Schnyder-Candrian S, Togbe D, Couillin I, et al. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med. 2006; 203: 2715-25
|
|
|
19) Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol. 2007; 7: 454-65
|
|
|
20) Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol. 2003; 4: 1169-76
|
|
|
21) Seki Y, Inoue H, Nagata N, et al. SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med. 2003; 9: 1047-54
|
|
|
22) Inoue H, Kubo M. SOCS proteins in T helper cell differentiation: implications for allergic disorders? Expert Rev Mol Med. 2004; 6: 1-11
|
|
|
23) Chen Z, Laurence A, Kanno Y, et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A. 2006; 103: 8137-42
|
|
|
24) Kinjyo I, Inoue H, Hamano S, et al. SOCS3 and STAT3 regulate TGF-beta production in CD4 helper T cell differentiation. J Exp Med. 2006; 203: 1021-31
|
|
|
25) Seki Y, Hayashi K, Matsumoto A, et al. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A. 2002; 99: 13003-8
|
|
|
26) Miyahara N, Swanson BJ, Takeda K, et al. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat Med. 2004; 10: 865-9
|
|
|
27) Stock P, Kallinich T, Akbari O, et al. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004; 34: 1817-27
|
|
|
28) Brender C, Tannahill GM, Jenkins BJ, et al. SOCS3 regulates CD8 T cell proliferation by inhibition of IL-6 and IL-27. Blood. 2007 (in press)
|
|
|
29) Akbari O, Faul JL, Hoyte EG, et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006; 354: 1117-29
|
|
|
30) Thomas SY, Lilly CM, Luster AD. Invariant natural killer T cells in bronchial asthma. N Engl J Med. 2006; 354: 2613-6; author reply. 2613-6
|
|
|
31) Vijayanand P, Seumois G, Pickard C, et al. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N Engl J Med. 2007; 356: 1410-22
|
|
|
32) Naka T, Tsutsui H, Fujimoto M, et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity. 2001; 14: 535-45
|
|
|
33) Hebenstreit D, Luft P, Schmiedlechner A, et al. IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site. J Immunol. 2003; 171: 5901-7
|
|
|
34) Hebenstreit D, Luft P, Schmiedlechner A, et al. SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells. Mol Immunol. 2005; 42: 295-303
|
|
|
35) Inoue H, Kato R, Fukuyama S, et al. Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. J Exp Med. 2005; 201: 73-82
|
|
|
36) Gagliardo R, Chanez P, Mathieu M, et al. Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma. Am J Respir Crit Care Med. 2003; 168: 1190-8
|
|
|
37) Nakao A, Sagara H, Setoguchi Y, et al. Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma. J Allergy Clin Immunol. 2002; 110: 873-8
|
|
|