|
1) Gordon RD, et al. Hypertension and severe hyperkalemia associated with suppression of rennin and aldosterone and completely reversed by dietary sodium restriction. Australas Ann Med. 1970; 4: 287-94
|
|
|
|
2) Wilson FH, et al. Human hypertension caused by mutations in WNK kinase. Science. 2001; 293: 1107-12
|
|
|
|
|
3) Bing-e Xu, et al. WNK1, a novel mammmarian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem. 2000; 275: 16795-801
|
|
|
|
|
|
4) Verissimo F, et al. WNK kinase, a novel protein kinase subfamily in multi-cellular organisms. Oncogene. 2001; 20: 5562-9
|
|
|
|
|
|
5) O'Reilly, M et al. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol. 2003; 14: 2447-56
|
|
|
|
|
|
6) Choate KA, et al. WNK1, a kinase mutated inherited hypertension with hyperkalemia, localizes to diverse Cl- transporting epithelia. Proc Natl Acad Sci U S A. 2003; 100: 663-8
|
|
|
|
|
|
7) Kahle KT, et al. WNK4 regulates apical and basolateral Cl-flux in extrarenal epithelia. Proc Natl Acad Sci U S A. 2004; 101: 2064-9
|
|
|
|
|
|
8) Scambelan M, et al. Mineralcorticoid resistant renal hyperkalemia without salt waisting (type II pseudohypoaldsteronism) role of increased renal chloride reabsorption. Kidney Int. 1981; 19: 716-27
|
|
|
|
|
|
9) Wilson FH, et al. Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A. 2003; 100: 680-4
|
|
|
|
|
|
10) Yang CL, et al. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003; 111: 1039-45
|
|
|
|
|
|
11) Kahle KT, et al. WNK4 regulates the balance between renal NaCl reabsorption and K＋ sectetion. Nature Genet. 2003; 35: 372-6
|
|
|
|
|
|
12) Yang SS, et al. Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells. Biochem Biophys Res Commun. 2004; 330: 410-4
|
|
|
|
|
|
13) Yamauchi K, et al. Disease-causing mutant WNK4 increases paracellular chloride perme-ability and phosphorylates claudin. Proc Natl Acad Sci U S A. 2004; 101: 4690-4
|
|
|
|
|
|
14) Kahle KT, Lifton RP, et al. Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension. Proc Natl Acad Sci U S A. 2004; 101: 14877-82
|
|
|
|
|
|
15) Tatum R, et al. WNK4 phosphorylates ser206 of claudin-7 and promotes paracellular Cl- permeability. FEBS Letters. 2007; 581: 3887-91
|
|
|
|
|
|
16) Yamauchi K, et al. Apical localozation of renal K channel was not altered in mutant WNK4 transgenic mice. Biochem Biophys Res Commun. 2005; 332: 750-5
|
|
|
|
|
|
17) Yang SS, et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a WNKD561/＋ knock-in mouse model. Cell metabolism. 2007; 5: 331-44
|
|
|
|
|
|
18) Piechotta K, et al. Characterization of the interaction of the stress kinase SAPK with the Na＋-K＋-2Cl- cotransporter in the nervous system. J Biol Chem. 2003; 278: 52848-56
|
|
|
|
|
|
19) Zambrowicz BP, et al. Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003; 100: 14109-14
|
|
|
|
|
|
20) Yang CL, et al. Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest. 2005; 115: 1379-87
|
|
|
|
|
|
21) Subramanya AR, et al. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Am J Physiol Renal Physiol. 2006; 290: 619-24
|
|
|
|
|