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1)Nakamura K. Central circuitries for body temperature regulation and fever. Am J Physiol Regul Integr Comp Physiol. 2011; 301: R1207-8
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2)Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009; 360: 1509-17
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3)Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009; 58: 1526-31
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4)van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009; 360: 1500-8
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5)Nakamura K, Matsumura K, Hubschle T, et al. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci. 2004; 24: 5370-80
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6)Kataoka N, Hioki H, Kaneko T, et al. Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia. Cell Metab. 2014; 20: 346-58
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7)Zhang Y, Kerman IA, Laque A, et al. Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci. 2011; 31: 1873-84
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8)Enriori PJ, Sinnayah P, Simonds SE, et al. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci. 2011; 31: 12189-97
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9)Rezai-Zadeh K, Yu S, Jiang Y, et al. Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake. Mol Metab. 2014; 3: 681-93
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10)Lkhagvasuren B, Nakamura Y, Oka T, et al. Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region. Eur J Neurosci. 2011; 34: 1442-52
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11)Nakamura K, Matsumura K, Kaneko T, et al. The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci. 2002; 22: 4600-10
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12)Nakamura K, Morrison SF. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2007; 292: R127-36
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13)Madden CJ, Morrison SF. Excitatory amino acid receptor activation in the raphe pallidus area mediates prostaglandin-evoked thermogenesis. Neuroscience. 2003; 122: 5-15
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14)Sarkar S, Zaretskaia MV, Zaretsky DV, et al. Stress- and lipopolysaccharide-induced c-fos expression and nNOS in hypothalamic neurons projecting to medullary raphe in rats: a triple immunofluorescent labeling study. Eur J Neurosci. 2007; 26: 2228-38
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15)Yoshida K, Li X, Cano G, et al. Parallel preoptic pathways for thermoregulation. J Neurosci. 2009; 29: 11954-64
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16)Zaretskaia MV, Zaretsky DV, DiMicco JA. Role of the dorsomedial hypothalamus in thermogenesis and tachycardia caused by microinjection of prostaglandin E2 into the preoptic area in anesthetized rats. Neurosci Lett. 2003; 340: 1-4
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17)Madden CJ, Morrison SF. Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2004; 286: R320-5
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18)Nakamura Y, Nakamura K, Matsumura K, et al. Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur J Neurosci. 2005; 22: 3137-46
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19)Stotz-Potter EH, Morin SM, DiMicco JA. Effect of microinjection of muscimol into the dorsomedial or paraventricular hypothalamic nucleus on air stress-induced neuroendocrine and cardiovascular changes in rats. Brain Res. 1996; 742: 219-24
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20)Morin SM, Stotz-Potter EH, DiMicco JA. Injection of muscimol in dorsomedial hypothalamus and stress-induced Fos expression in paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol. 2001; 280: R1276-84
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21)Elmquist JK, Ahima RS, Elias CF, et al. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci U S A. 1998; 95: 741-6
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22)Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996; 382: 250-2
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23)Nakamura K, Morrison SF. A thermosensory pathway that controls body temperature. Nat Neurosci. 2008; 11: 62-71
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24)Nakamura K, Morrison SF. A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci U S A. 2010; 107: 8848-53
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25)Nakayama T, Eisenman JS, Hardy JD. Single unit activity of anterior hypothalamus during local heating. Science. 1961; 134: 560-1
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26)Matsumura K, Cao C, Ozaki M, et al. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J Neurosci. 1998; 18: 6279-89
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27)Yamagata K, Matsumura K, Inoue W, et al. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci. 2001; 21: 2669-77
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28)Wilhelms DB, Kirilov M, Mirrasekhian E, et al. Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever. J Neurosci. 2014; 34: 11684-90
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29)Nakamura K, Kaneko T, Yamashita Y, et al. Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci Lett. 1999; 260: 117-20
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30)Nakamura K, Kaneko T, Yamashita Y, et al. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J Comp Neurol. 2000; 421: 543-69
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31)Lazarus M, Yoshida K, Coppari R, et al. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007; 10: 1131-3
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32)Nakamura Y, Nakamura K, Morrison SF. Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions. Neuroscience. 2009; 161: 614-20
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33)Chen XM, Hosono T, Yoda T, et al. Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats. J Physiol. 1998; 512: 883-92
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