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5)Satoh H, Amagase K, Takeuchi K. Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility. J Pharmacol Exp Ther. 2012; 343: 270-7
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8)LoGuidice A, Wallace BD, Bendel L, et al. Pharmacologic targeting of bacterial beta-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. J Pharmacol Exp Ther. 2012; 341: 447-54
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9)Zhu Y, Zhang QY. Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine. J Pharmacol Exp Ther. 2012; 343: 362-70
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11)Kato S, Matsuda N, Matsumoto K, et al. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Pharmacol Res. 2012; 66: 226-34
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12)Satoh H, Amagase K, Takeuchi K. Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats. J Pharmacol Exp Ther. 2014; 348: 227-35
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13)Nagano Y, Matsui H, Shimokawa O, et al. Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells. J Physiol Pharmacol. 2012; 63: 137-42
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14)Kurokawa S, Katsuki S, Fujita T, et al. A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury. J Gastroenterol. 2014; 49: 239-44
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15)Mizukami K, Murakami K, Abe T, et al. Aspirin-induced small bowel injuries and the preventive effect of rebamipide. World J Gastroenterol. 2011; 17: 5117-22
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17)Isomura Y, Yamaji Y, Yamada A, et al. Irsogladine improves small-intestinal injuries in regular users of nonsteroidal anti-inflammatory drugs. Gastrointest Endosc. 2014; 80: 118-25
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18)Watari I, Oka S, Tanaka S, et al. Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study. BMC Gastroenterol. 2013; 13: 108
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19)Hayashi S, Kurata N, Yamaguchi A, et al. Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors. J Pharmacol Exp Ther. 2014; 349: 470-9
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20)Amagase K, Yoshida Y, Hara D, et al. Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats. J Physiol Pharmacol. 2013; 64: 65-75
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21)Yamamoto A, Itoh T, Nasu R, et al. Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats. World J Gastroenterol. 2014; 20: 2641-52
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23)Kume H, Okazaki K, Takahashi T, et al. Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats. Clin Nutr. 2014; 33: 1140-6
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24)Tuo B, Wen G, Wei J, et al. Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum. Gastroenterology. 2011; 141: 854-63
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26)Khomenko T, Deng X, Ahluwalia A, et al. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Dig Dis Sci. 2014; 59: 297-306
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27)Guillemot L, Schneider Y, Brun P, et al. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012; 125: 5005-14
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28)Choi KS, Kim EH, Hong H, et al. Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A2/5-lipoxygenase and activating gamma-glutamylcysteine synthetase. J Gastroenterol Hepatol. 2012; 27 Suppl 3: 13-22
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29)岡部治弥,崎村正弘.仮称“非特異性多発性小腸潰瘍症”.胃と腸.1968; 3: 1539-49
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30)Matsumoto T, Kubokura N, Matsui T, et al. Chronic nonspecific multiple ulcer of the small intestine segregates in offspring from consanguinity. J Crohns Colitis. 2011; 5: 559-65
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