1)Fevold HL, Hisaw FL, Meyer RK. The relaxative hormone of the corpus luterum. Its purification and concentration. J Am Chem Soc. 1930; 52: 3340-8
|
|
|
2)Samuel CS, Hewitson TD. Relaxin in cardiovascular and renal disease. Kidney Int. 2006; 69: 1498-502
|
|
|
3)Du X-J, Hewitson TD, Nguyen M-N, et al. Therapeutic effects of serelaxin in acute heart failure. Circ J. 2014; 78: 542-52
|
|
|
4)Teichman SL, Unemori E, Teerlink JR, et al. Relaxin: Review of biology and potential role in treating heart failure. Curr Heart Fail Rep. 2010; 7: 75-82
|
|
|
5)Teerlink JR, Metro M, Felker GM, et al. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicenter, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet. 2009; 373: 1429-39
|
|
|
6)Sato N, Takahashi W, Hirayama A, et al. Multicenter, randomized, double-blinded, placebo-controlled phase II study of serelaxin in Japanese patients with acute heart failure. Circ J. 2015; 79: 1237-47
|
|
|
7)Dahlke M, Ng D, Yamaguchi M, et al. Safety and tolerability of serelaxin, a recombinant human relaxin-2 in development for the treatment of acute heart failure, in healthy Japanese volunteers and a comparison of pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian populations. J Clin Pharmacol. 2015; 55: 415-22
|
|
|
8)Teerlink JR, Cotter G, Davison BA, et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-ANF): a randomised, placebo-controlled trial. Lancet. 2013; 381: 29-39
|
|
|
9)Ponikowski P, Mitrovic V, Ruda M, et al. A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure. Eur Heart J. 2014; 35: 431-41
|
|
|
10)Metra M, Cotter G, Davison BA, et al. Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the relaxin in acute heart failure (RELAX-HF) development program: correlation with outcomes. J Am Coll Cardiol. 2013; 61: 196-206
|
|
|
11)Voors AA, Davison BA, Felker GM, et al. Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF. Eur J Heart Fail. 2011; 13: 961-7
|
|
|