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2) Rosenberger C, Mandriota S, Jurgensen JS, et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol. 2002; 13: 1721-32
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PubMed
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21) Nishi H, Inagi R, Kato H, et al. Hemoglobin is expressed by mesangial cells and reduces oxidant stress. J Am Soc Nephrol. 2008; 19: 1500-8
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22) Bhaskaran M, Chen H, Chen Z, et al. Hemoglobin is expressed in alveolar epithelial type II cells. Biochem Biophys Res Commun. 2005; 333: 1348-52
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23) Newton DA, Rao KM, Dluhy RA, et al. Hemoglobin is expressed by alveolar epithelial cells. J Biol Chem. 2006; 281: 5668-76
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24) Grek CL, Newton DA, Spyropoulos DD, et al. Hypoxia upregulates expression of hemoglobin in alveolar epithelial cells. Am J Respir Cell Mol Biol. (accepted)
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25) Schelshorn DW, Schneider A, Kuschinsky W, et al. Expression of hemoglobin in rodent neurons. J Cereb Blood Flow Metab. 2009; 29: 585-95
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26) Leffers H, Navarro VM, Nielsen JE, et al. Increased expression of alpha- and beta-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat. J Steroid Biochem Mol Biol. 2006; 99: 33-43
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27) Biagioli M, Pinto M, Cesselli D, et al. Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proc Natl Acad Sci U S A. 2009; 106: 15454-9
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30) Gelman JS, Fricker LD. Hemopressin and other bioactive peptides from cytosolic proteins: are these non-classical neuropeptides? AAPS J. 2010; 12: 279-89
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31) He Y, Hua Y, Lee JY, et al. Brain alpha- and beta-globin expression after intracerebral hemorrhage. Transl Stroke Res. 2010; 1: 48-56
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32) Masuoka N, Kodama H, Abe T, et al. Characterization of hydrogen peroxide removal reaction by hemoglobin in the presence of reduced pyridine nucleotides. Biochim Biophys Acta. 2003; 1637: 46-54
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34) Widmer CC, Pereira CP, Gehrig P, et al. Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase. Antioxid Redox Signal. 2010; 12: 185-98
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35) Tezel G, Yang X, Luo C, et al. Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation. Invest Ophthalmol Vis Sci. 2010; 51: 907-19
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36) Trent JT 3rd, Hargrove MS. A ubiquitously expressed human hexacoordinate hemoglobin. J Biol Chem. 2002; 277: 19538-45
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37) Burmester T, Ebner B, et al. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Mol Biol Evol. 2002; 19: 416-21
PubMed
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38) Sugimoto H, Makino M, Sawai H, et al. Structural basis of human cytoglobin for ligand binding. J Mol Biol. 2004; 339: 873-85
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39) Sawai H, Kawada N, Yoshizato K, et al. Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry. 2003; 42: 5133-42
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40) Shivapurkar N, Stastny V, Okumura N, et al. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Res. 2008; 68: 7448-56
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41) Shaw RJ, Omar MM, Rokadiya S, et al. Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Br J Cancer. 2009; 101: 139-44
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42) Singh S, Manda SM, Sikder D, et al. Calcineurin activates cytoglobin transcription in hypoxic myocytes. J Biol Chem. 2009; 284: 10409-21
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43) Schmidt M, Gerlach F, Avivi A, et al. Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia. J Biol Chem. 2004; 279: 8063-9
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44) Fordel E, Geuens E, Dewilde S, et al. Hypoxia/ischemia and the regulation of neuroglobin and cytoglobin expression. IUBMB Life. 2004; 56: 681-7
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45) Fordel E, Geuens E, Dewilde S, et al. Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR. Biochem Biophys Res Commun. 2004; 319: 342-8
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46) Guo X, Philipsen S, Tan-Un KC. Study of the hypoxia-dependent regulation of human CYGB gene. Biochem Biophys Res Commun. 2007; 364: 145-50
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47) Fordel E, Thijs L, Martinet W, et al. Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death. Neurosci Lett. 2006; 410: 146-51
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48) Li D, Chen XQ, Li WJ, et al. Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress. Neurochem Res. 2007; 32: 1375-80
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49) Hodges NJ, Innocent N, Dhanda S, et al. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. Mutagenesis. 2008; 23: 293-8
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50) Xu R, Harrison PM, Chen M, et al. Cytoglobin overexpression protects against damage-induced fibrosis. Mol Ther. 2006; 13: 1093-100
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51) Picard N, Baum O, Vogetseder A, et al. Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem Cell Biol. 2008; 130: 141-55
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52) Nakatani K, Okuyama H, Shimahara Y, et al. Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Lab Invest. 2004; 84: 91-101
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53) Nishi H, Inagi R, Kawada N, et al. Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions. Am J Pathol. (accepted)
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54) Fine LG, Orphanides C, Norman JT. Progressive renal disease: the chronic hypoxia hypothesis. Kidney Int Suppl. 1998; 65: S74-8
PubMed
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55) Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol. 2006; 17: 17-25
PubMed
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56) Nangaku M, Eckardt KU. Hypoxia and the HIF system in kidney disease. J Mol Med. 2007; 85: 1325-30
PubMed
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57) Nangaku M, Nishi H, Miyata T. Role of chronic hypoxia and hypoxia inducible factor in kidney disease. Chin Med J (Engl). 2008; 121: 257-64
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58) Fine LG, Norman JT. Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int. 2008; 74: 867-72
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59) Neilson EG. Mechanisms of disease: Fibroblasts - a new look at an old problem. Nat Clin Pract Nephrol. 2006; 2: 101-8
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60) Palm F, Nangaku M, Fasching A, et al. Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress. Am J Physiol Renal Physiol (accepted)
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61) Rosenberger C, Griethe W, Gruber G, et al. Cellular responses to hypoxia after renal segmental infarction. Kidney Int. 2003; 64: 874-86
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62) Mimura I, Nangaku M, Nishi H. Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney. Am J Physiol Renal Physiol (accepted)
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63) Arab S, Konstantinov IE, Boscarino C, et al. Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery. J Thorac Cardiovasc Surg. 2007; 134: 74-81, 81 e71-72
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